Evidence map›Paper›PMID 32642907›Full record

ArticleEJNMMI research2020

Selective serotonin reuptake inhibitors (SSRIs) prevent meta-iodobenzylguanidine (MIBG) uptake in platelets without affecting neuroblastoma tumor uptake.

Thomas Blom, Rutger Meinsma, Marja Rutgers, Corine Buitenhuis, Marieke Dekken-Van den Burg, André B P van Kuilenburg, Godelieve A M Tytgat

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Thomas BlomPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Rutger MeinsmaGastroenterology & Metabolism, Department of Clinical Chemistry, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Marja RutgersDepartment of Experimental Therapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Corine BuitenhuisDepartment of Experimental Therapy, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Marieke Dekken-Van den BurgDepartment of Pediatric Oncology, Emma Children's Hospital, Amsterdam University Medical Center, Amsterdam, The Netherlands.
André B P van KuilenburgGastroenterology & Metabolism, Department of Clinical Chemistry, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Godelieve A M TytgatPrincess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. g.a.m.tytgat@prinsesmaximacentrum.nl.ORCID http://orcid.org/0000-0003-4452-0748
Princess Máxima Center · NLThe Netherlands Cancer Institute · NLEmma Kinderziekenhuis · NL

Funding

Dutch Cancer Society NKI 94-084European Community BMH4-CT98-3297Foundation for Pediatric Cancer Research No 93-011
6 · The paper itself

Abstract

backgroundThe therapeutic use of [

methodsTo determine the transport kinetics of SERT for [

resultsSERT performed as a low-affinity transporter of [

conclusionOur study demonstrates for the first time that SSRIs selectively inhibit MIBG uptake in platelets without affecting MIBG accumulation in an in vivo neuroblastoma model. The concomitant application of citalopram during [

Indexed as

Hematological toxicityMeta-iodobenzylguanidine (MIBG)PlateletsSelective serotonin reuptake inhibitor (SSRI)Thrombocytopenia

Identifiers

PMID32642907
PMCPMC7343696
OpenAlexW3041257415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.