ArticleDNA research : an international journal for rapid publication of reports on genes and genomes2020
Genome assembly of Chiococca alba uncovers key enzymes involved in the biosynthesis of unusual terpenoids.
Article in DNA research : an international journal for rapid publication of reports on genes and genomes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 14 citations in OpenAlex.
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- Genome and Tissue-Specific Transcriptome of the Tropical Milkweed (Plant direct · 2025Article
- A near-complete genome assembly of Cinchona calisaya.Scientific data · 2025Article
- Genome mining of metabolic gene clusters in the Rubiaceae family.Computational and structural biotechnology journal · 2024Article
- Insights from the first chromosome-level genome assembly of the alpine gentian Gentiana straminea Maxim.DNA research : an international journal for rapid publication of reports on genes and genomes · 2024Article
- Complete chloroplast genome sequence of the medicinal plantMitochondrial DNA. Part B, Resources · 2024Article
- EngineeringmLife · 2023Article
- Article
- The Current Developments in Medicinal Plant Genomics Enabled the Diversification of Secondary Metabolites' Biosynthesis.International journal of molecular sciences · 2022Review
- A highly contiguous, scaffold-level nuclear genome assembly for the fever tree (GigaByte (Hong Kong, China) · 2022Article
- Comparative Mitogenomic Analysis Reveals Gene and Intron Dynamics in Rubiaceae and Intra-Specific Diversification inInternational journal of molecular sciences · 2021Article
- Review on the Development and Applications of Medicinal Plant Genomes.Frontiers in plant science · 2021Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chiococca alba (L.) Hitchc. (snowberry), a member of the Rubiaceae, has been used as a folk remedy for a range of health issues including inflammation and rheumatism and produces a wealth of specialized metabolites including terpenes, alkaloids, and flavonoids. We generated a 558 Mb draft genome assembly for snowberry which encodes 28,707 high-confidence genes. Comparative analyses with other angiosperm genomes revealed enrichment in snowberry of lineage-specific genes involved in specialized metabolism. Synteny between snowberry and Coffea canephora Pierre ex A. Froehner (coffee) was evident, including the chromosomal region encoding caffeine biosynthesis in coffee, albeit syntelogs of N-methyltransferase were absent in snowberry. A total of 27 putative terpene synthase genes were identified, including 10 that encode diterpene synthases. Functional validation of a subset of putative terpene synthases revealed that combinations of diterpene synthases yielded access to products of both general and specialized metabolism. Specifically, we identified plausible intermediates in the biosynthesis of merilactone and ribenone, structurally unique antimicrobial diterpene natural products. Access to the C. alba genome will enable additional characterization of biosynthetic pathways responsible for health-promoting compounds in this medicinal species.
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