ArticleNeuro-oncology advances
Effect of radiation therapy on cerebral cortical thickness in glioma patients: Treatment-induced thinning of the healthy cortex.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Neurocognitive outcomes in patients with brain metastases: a systematic review.The Lancet. Oncology · 2025Pooled it
- The Impact of Stereotactic or Whole Brain Radiotherapy on Neurocognitive Functioning in Adult Patients with Brain Metastases: A Systematic Review and Meta-Analysis.Oncology research and treatment · 2021Pooled it
- Hippocampal avoidance prophylactic cranial irradiation (HA-PCI) for small cell lung cancer reduces hippocampal atrophy compared to conventional PCI.Neuro-oncology · 2023Trial
- Negative impact of hippocampal radiotherapy dose on memory function in patients with brain metastases.Neuro-oncology practice · 2026Article
- Longitudinal cortical thickness changes in children with posterior fossa tumors.Neuro-oncology practice · 2026Article
- Decreased overall survival in patients with brain metastases from non-small cell lung cancer with radiotherapy dose on the neurogenic niches.Technical innovations & patient support in radiation oncology · 2026Article
- Elucidating the complexity of radiation-induced brain injury: comprehensive assessment of hippocampal and cortical impacts.Journal of neuro-oncology · 2025Article
- Trajectories of Cortical Atrophy Differ According to Cognitive Phenotype in Adults With Primary Brain Tumors.International journal of radiation oncology, biology, physics · 2025Observational
- Early region-specific impact of adjuvant radiation therapy on cognition and quality of life in adult patients with primary brain tumors.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Cortical thickness deviations as biomarker for subtyping and prognosis in pediatric brainstem tumors.Scientific reports · 2025Article
- Baseline total brain volume predicts changes in quality of life and overall survival after cranial radiotherapy in older patients with glioblastoma: Results from the prospective BRITER study.Neuro-oncology practice · 2024Article
- Individualized trajectories in postradiotherapy neurocognitive functioning of patients with brain metastases.Neuro-oncology practice · 2024Article
- Precision based approach to tailoring radiotherapy in the multidisciplinary management of pediatric central nervous system tumors.Journal of the National Cancer Center · 2023Review
- Voxel based morphometry-detected white matter volume loss after multi-modality treatment in high grade glioma patients.PloS one · 2023Article
- Morphological changes after cranial fractionated photon radiotherapy: Localized loss of white matter and grey matter volume with increasing dose.Clinical and translational radiation oncology · 2021Article
- Microglia in Cancer Therapy-Related Cognitive Impairment.Trends in neurosciences · 2021Review
- Intracranial long-term complications of radiation therapy: an image-based review.Neuroradiology · 2021Review
- Review
- Height, weight, and cardiovascular effects of stimulants on children with brain tumors.Pediatric blood & cancer · 2021Article
- Automatic Radiotherapy Planning for Glioblastoma Radiotherapy With Sparing of the Hippocampus and nTMS-Defined Motor Cortex.Frontiers in neurology · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith overall survival of brain tumors improving, radiation induced brain injury is becoming an increasing issue. One of the effects of radiation therapy (RT) is thinning of the cerebral cortex, which could be one of the factors contributing to cognitive impairments after treatment. In healthy brain, cortex thickness varies between 1 and 4.5 mm. In this study, we assess the effect of RT on the thickness of the cerebral cortex and relate the changes to the local dose.
methodsWe identified 28 glioma patients with optimal scan quality. Clinical CTs and MRIs at baseline and 1 year post-RT were collected and coregistered. The scans were processed via an automated image processing pipeline, which enabled measuring changes of the cortical thickness, which were related to local dose.
resultsThree areas were identified where significant dose-dependent thinning occurred, with thinning rates of 5, 6, and 26 μm/Gy after 1 year, which corresponds to losses of 5.4%, 7.2%, and 21.6% per 30 Gy per year. The first area was largely located in the right inferior parietal, supramarginal, and superior parietal regions, the second in the right posterior cingulate and paracentral regions, and the third almost completely in the right lateral orbital frontal region.
conclusionsWe have identified three areas susceptible to dose-dependent cortical thinning after radiation therapy. Should future prospective studies conclude that irradiation of these areas lead to cognitive decline, they need to be spared in order to prevent this debilitating consequence of treatment.
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