ArticleNeuro-oncology advances
Gliomas display distinct sex-based differential methylation patterns based on molecular subtype.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Gene regulatory network analysis identifies dysregulation of hypoxia pathways as contributing to glioblastoma treatment resistance in females.Biology of sex differences · 2026Article
- Gene regulatory network analysis identifies dysregulation of hypoxia pathways as contributing to glioblastoma multiforme treatment resistance in females.medRxiv : the preprint server for health sciences · 2026Article
- Gender and sex interactions are intrinsic components of cancer phenotypes.Nature reviews. Cancer · 2025Review
- Do clinical outcomes in individuals with malignant gliomas differ between sexes?Brain & spine · 2025Article
- Epigenetic developmental mechanisms underlying sex differences in cancer.The Journal of clinical investigation · 2024Review
- Sex Differences in Odds of Brain Metastasis and Outcomes by Brain Metastasis Status after Advanced Melanoma Diagnosis.Cancers · 2024Article
- Sex-related incidence and survival differences in pediatric high-grade glioma subtypes: A population-based cohort study.iScience · 2023Article
- Disclosing transcriptomics network-based signatures of glioma heterogeneity using sparse methods.BioData mining · 2023Article
- Deciphering gliomagenesis from genome-wide association studies.Neuro-oncology · 2023Article
- An End-to-endProceedings. IEEE International Conference on Healthcare Informatics · 2023Article
- Sex differences in methylation profiles are apparent in medulloblastoma, particularly among SHH tumors.Frontiers in oncology · 2023Article
- Sex-specific molecular differences in glioblastoma: assessing the clinical significance of genetic variants.Frontiers in oncology · 2023Review
- The sex-dependent role of the androgen receptor in glioblastoma: results of molecular analyses.Molecular oncology · 2022Article
- Racial/ethnic and sex differences in young adult malignant brain tumor incidence by histologic type.Cancer epidemiology · 2022Article
- Importance of the intersection of age and sex to understand variation in incidence and survival for primary malignant gliomas.Neuro-oncology · 2022Article
- Sex Differences in Glioblastoma-Findings from the Swedish National Quality Registry for Primary Brain Tumors between 1999-2018.Journal of clinical medicine · 2022Article
- Functional Characterization of Brain Tumor-Initiating Cells and Establishment of GBM Preclinical Models that Incorporate Heterogeneity, Therapy, and Sex Differences.Molecular cancer therapeutics · 2021Article
- NFAT5-Mediated Signalling Pathways in Viral Infection and Cardiovascular Dysfunction.International journal of molecular sciences · 2021Review
- Sex Disparities inJournal of clinical medicine · 2021Article
- Sex-specific aspects of epidemiology, molecular genetics and outcome: primary brain tumours.ESMO open · 2020Review
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Funding
Abstract
backgroundGliomas are the most common type of primary brain tumor and one of many cancers where males are diagnosed with greater frequency than females. However, little is known about the sex-based molecular differences in glioblastomas (GBMs) or lower grade glioma (non-GBM) subtypes. DNA methylation is an epigenetic mechanism involved in regulating gene transcription. In glioma and other cancers, hypermethylation of specific gene promoters downregulates transcription and may have a profound effect on patient outcome. The purpose of this study was to determine if sex-based methylation differences exist in different glioma subtypes.
methodsMolecular and clinical data from glioma patients were obtained from The Cancer Genome Atlas and grouped according to tumor grade and molecular subtype (
resultsAnalysis of methylation data in 4 glioma subtypes revealed unique sets of both sex-specific DMPs and DMRs in each subtype. Motif analysis based on DMP position also identified distinct sex-based sets of DNA-binding motifs that varied according to glioma subtype. Downstream targets of 2 of the GBM-specific transcription binding sites,
conclusionDNA methylation differences between males and females in 4 glioma molecular subtypes suggest an important, sex-specific role for DNA methylation in epigenetic regulation of gliomagenesis.
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