ArticleContemporary clinical trials communications2020
The promotion of physical activity for the prevention of Alzheimer's disease in adults with Down Syndrome: Rationale and design for a 12 Month randomized trial.
Article in Contemporary clinical trials communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04048759 (The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome), which is not on this map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Promotion of Physical Activity for the Prevention of Alzheimer's Disease in Adults With Down Syndrome
Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Outcomes of an Exercise Intervention in Adults With Down Syndrome and Congenital Heart Disease: A Secondary Analysis.Journal of intellectual disability research : JIDR · 2026Trial
- Daily physical activity and cardiorespiratory fitness in adults with Down syndrome with and without congenital heart disease.Disability and health journal · 2025Trial
- The association of increased body mass index on cardiorespiratory fitness, physical activity, and cognition in adults with down syndrome.Disability and health journal · 2023Trial
- Pilot evaluation of a dance-based physical activity program for adults with Down syndrome.Translational journal of the American College of Sports Medicine · 2026Article
- Caregiving for Adults With Down Syndrome: Caregiver Experiences and Support Needs.Journal of applied research in intellectual disabilities : JARID · 2025Article
- Alzheimer's Disease Research Center Down Syndrome Cores: Experience from two sites.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Charting the future: current and future directions in translational research for individuals with Down syndrome.Journal of neurodevelopmental disorders · 2025Review
- The association between cardiorespiratory fitness and resting-state functional connectivity in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Successful Online Exercise Intervention Studies for Individuals With Intellectual Disabilities Including Down Syndrome: Best Practices and Recommendations.Journal of applied research in intellectual disabilities : JARID · 2025Article
- Factors Associated With Depression in Caregivers of Adults With Down Syndrome.Journal of intellectual disability research : JIDR · 2025Article
- Impact of Physical Activity on Autonomy and Quality of Life in Individuals with Down Syndrome: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Physical Activity Patterns in Adolescents and Adults with Intellectual and Developmental Disabilities.Exercise, sport & movement · 2024Article
- The association between cardiovascular health and cognition in adults with Down syndrome.Journal of neurodevelopmental disorders · 2023Article
- A flexible test for early-stage studies with multiple endpoints.Journal of applied statistics · 2023Article
- Markov model combined with MR diffusion tensor imaging for predicting the onset of Alzheimer's disease.Open life sciences · 2023Article
- Review
- The promotion of physical activity for use in Alzheimer's disease prevention trials in adults with Down syndrome: Results from a 12-month randomized trial.Alzheimer's & dementia (New York, N. Y.)Article
- The association of dementia risk symptoms and functional activity in adults with Down syndrome.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Nearly all individuals with Down Syndrome (DS) display pathology associated with Alzheimer's disease (AD) beginning as early as age 30. Previous research in typically developed adults suggests that increased moderate-to-vigorous physical activity (MVPA) may improve cognitive function and protect against age-related structural and functional changes in the brain; however, the potential impact of increased MVPA on the development of AD in adults with DS has not been evaluated. Despite the potential positive impact of MVPA on cognition and AD risk, participation in MVPA among young adults with DS is low. The limited research evaluating strategies for increasing MVPA in adults with DS has been unsuccessful in increasing MVPA. Results from our preliminary investigation where we remotely delivered real-time MVPA, led by a trained health educator, to groups of adults with DS in their homes via video conferencing on a tablet computer demonstrated high attendance, increased MVPA during group sessions, and improvements in cognitive function. However, the sustainability, impact on total daily MVPA, optimal session frequency, and potential impacts on cognitive function and brain health of remotely delivered group MVPA sessions in adults with DS are unknown. Therefore, we will conduct a trial in 80 non-demented adults with DS to determine the feasibility and potential efficacy of remotely delivered group MVPA sessions to increase daily MVPA, relative to a usual care control. Secondarily we will assess the impact of MVPA on cardiovascular fitness, quality of life, cognitive function and brain parameters related to AD. NCT REGISTRATION: NCT04048759.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.