ArticleMaxillofacial plastic and reconstructive surgery2020
4-Hexylresorcinol-in duced angiogenesis potential in human endothelial cells.
Article in Maxillofacial plastic and reconstructive surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 28 citations in OpenAlex.
- Therapeutic potential of 4-hexylresorcinol in reducing sarcopenia in diabetic masseter muscle.Maxillofacial plastic and reconstructive surgery · 2025Article
- The Role of Natural Products in Diabetic Retinopathy.Biomedicines · 2024Review
- Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models.BMC ophthalmology · 2023Review
- Effects of 4-hexylresorcinol administration on the submandibular glands in a growing rat model.Head & face medicine · 2022Article
- 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing.Maxillofacial plastic and reconstructive surgery · 2022Review
- Article
- The effect of 4-hexylresorinol administration on NAD+ level and SIRT activity in Saos-2 cells.Maxillofacial plastic and reconstructive surgery · 2021Article
- Effects of 4-Hexylresorcinol on Craniofacial Growth in Rats.International journal of molecular sciences · 2021Article
- Zinc Sulfate Stimulates Osteogenic Phenotypes in Periosteum-Derived Cells and Co-Cultures of Periosteum-Derived Cells and THP-1 Cells.Life (Basel, Switzerland) · 2021Article
- Increased Level of Vascular Endothelial Growth Factors by 4-hexylresorcinol is Mediated by Transforming Growth Factor-β1 and Accelerates Capillary Regeneration in the Burns in Diabetic Animals.International journal of molecular sciences · 2020Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background4-Hexylresorcinol (4HR) is able to increase angiogenesis. However, its molecular mechanism in the human endothelial cells has not been clarified.
methodsAs endothelial cells are important in angiogenesis, we treated the human umbilical vein endothelial cells (HUVECs) with 4HR and investigated protein expressional changes by immunoprecipitation high-performance liquid chromatography (IP-HPLC) using 96 antisera.
resultsHere, we found that 4HR upregulated transforming growth factor-β (TGF-β)/SMAD/vascular endothelial growth factor (VEGF) signaling, RAF-B/ERK and p38 signaling, and M2 macrophage polarization pathways. 4HR also increased expression of caspases and subsequent cellular apoptosis. Mechanistically, 4HR increased TGF-β1 production and subsequent activation of SMADs/VEGFs, RAF-B/ERK and p38 signaling, and M2 macrophage polarization.
conclusionCollectively, 4HR activates TGF-β/SMAD/VEGF signaling in endothelial cells and induced vascular regeneration and remodeling for wound healing.
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