ArticleJournal of thoracic disease2020
The growth feature and its diagnostic value for benign and malignant pulmonary nodules met in routine clinical practice.
Article in Journal of thoracic disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- ACR Appropriateness Criteria® Indolent Lung Cancer.Journal of the American College of Radiology : JACR · 2026Guideline
- A narrative review on CT-based evaluation and prediction of lung nodule growth: current status and future directions.Translational lung cancer research · 2026Review
- Training set augmentation and biology-aware harmonization improve radiomic models for lung cancer prediction in indeterminate nodules.Scientific reports · 2026Article
- The role of growth heterogeneity in solid nodular non-small cell lung cancer in clinical practice: a narrative review.Journal of thoracic disease · 2026Review
- Biopsy-Proven Pulmonary Tumors Detected by LDCT: A 10-Year Single-Center Study of Growth Patterns and Diagnostic Pitfalls.International journal of medical sciences · 2026Article
- Influencing factors and prediction of growth heterogeneity in solid nodule non-small cell lung cancer based on artificial intelligence: a prospective study.Translational lung cancer research · 2025Article
- Training Set Augmentation and Harmonization Enables Radiomic Models to Detect Early Onset of Lung Cancer.Research square · 2025Article
- Exploring and verifying key thin-section computed tomography features for accurately differentiating granulomas and peripheral lung cancers.Journal of thoracic disease · 2025Article
- Minimally invasive biomarkers for triaging lung nodules-challenges and future perspectives.Cancer metastasis reviews · 2025Review
- Pulmonary Smooth Muscle Hyperplasia Difficult to Differentiate from Primary Lung Cancer: A Case Report.Surgical case reports · 2025Article
- Enhancing survival predictions in lung cancer with cystic airspaces: a multimodal approach combining clinical and radiomic features.Frontiers in oncology · 2025Article
- Cost-Effectiveness of Rapid On-Site Evaluation During Navigational Bronchoscopy.CHEST pulmonary · 2024Article
- Testosterone, β-estradiol, and hepatocellular carcinoma: stimulation or inhibition? A comparative effect analysis on cell cycle, apoptosis, and Wnt signaling of HepG2 cells.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Growth characteristics of early-stage (IA) lung adenocarcinoma and its value in predicting lymph node metastasis.Cancer imaging : the official publication of the International Cancer Imaging Society · 2023Article
- Factors associated with overdiagnosis of benign pulmonary nodules as malignancy: a retrospective cohort study.BMC pulmonary medicine · 2023Article
- Time-distance vision transformers in lung cancer diagnosis from longitudinal computed tomography.Proceedings of SPIE--the International Society for Optical Engineering · 2023Article
- Molecular characteristics of multiple primary pulmonary nodules under a three-dimensional reconstruction model and relevant multi-omics analyses: a case report.Frontiers in oncology · 2023Article
- Correlation and significance of COX-2, Ki67, VEGF and other immune indexes with the growth of malignant pulmonary nodules.Journal of cardiothoracic surgery · 2022Article
- Deep learning-based growth prediction for sub-solid pulmonary nodules on CT images.Frontiers in oncology · 2022Article
- Preoperative Changes of Lung Nodule on Computed Tomography and Their Relationship With Pathological Outcomes.Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowth rate is an independent risk factor for lung cancer in screened pulmonary nodules. This study aimed to clarify growth characteristics of pulmonary nodules in routine clinical practice and examine whether volume doubling time (VDT) can predict the malignancy of these nodules.
methodsWe retrospectively enrolled patients with 5-30-mm-sized pulmonary nodules that had been surgically resected after a follow-up of at least 3 months. Two follow-up computed tomography (CT) images with similar thickness and long interval were obtained. Then, three-dimensional (3D) manual segmentation for all nodules was performed on two follow-up CT scans. Subsequently, VDT was calculated for nodules with a change in volume of at least 25%.
resultsOverall, 305 pulmonary nodules in 305 patients (men, 36.7%; median age, 57) were included. The mean increased diameter, mass, and volume of benign (n=86) and malignant (n=219) nodules were 0.09
conclusionsIn routine clinical practice, many malignant nodules could grow slowly or even remain stable over time. Regarding growing nodules, the diagnostic value of VDT was limited.
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