ArticleTheranostics2020
Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- The vascular niche: an orchestrator of the spatiotemporal dynamics of distant metastasis.Acta pharmacologica Sinica · 2026Review
- Role of elevation of glycolysis in tumor-associated macrophages in glioblastoma immune evasion and therapeutic implications.PNAS nexus · 2026Review
- Huayu Wan enhances immune checkpoint inhibitor efficacy in triple-negative breast cancer by normalizing tumor vasculature and remodeling the tumor immune microenvironment.Frontiers in immunology · 2026Article
- Angiogenesis and Resistance Mechanisms in Glioblastoma: Targeting Alternative Vascularization Pathways to Overcome Therapy Resistance.Current pharmaceutical design · 2026Review
- Metabolic reprogramming and immunosenescence: a new sight for glioma therapy.Frontiers in cell and developmental biology · 2026Review
- Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis.American journal of physiology. Heart and circulatory physiology · 2025Review
- Role of dynamic contrast-enhanced and dynamic susceptibility contrast imaging in evaluating the biological features of glioma.Quantitative imaging in medicine and surgery · 2025Article
- Galunisertib promotes bevacizumab-induced vascular normalization in nasopharyngeal carcinoma: Multi-parameter MRI evaluation.Molecular therapy. Oncology · 2024Article
- Glycolytic PFKFB3 and Glycogenic UGP2 Axis Regulates Perfusion Recovery in Experimental Hind Limb Ischemia.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Targeting glycolysis: exploring a new frontier in glioblastoma therapy.Frontiers in immunology · 2024Review
- Role of Glycolytic and Glutamine Metabolism Reprogramming on the Proliferation, Invasion, and Apoptosis Resistance through Modulation of Signaling Pathways in Glioblastoma.International journal of molecular sciences · 2023Review
- Targeting of endothelial cells in brain tumours.Clinical and translational medicine · 2023Review
- Modulating Glycolysis to Improve Cancer Therapy.International journal of molecular sciences · 2023Review
- Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma.Frontiers in immunology · 2023Article
- Targeting PELP1 Attenuates Angiogenesis and Enhances Chemotherapy Efficiency in Colorectal Cancer.Cancers · 2022Article
- Resistance Mechanisms of the Metastatic Tumor Microenvironment to Anti-Angiogenic Therapy.Frontiers in oncology · 2022Review
- Inhibition of PFKFB Preserves Intestinal Barrier Function in Sepsis by Inhibiting NLRP3/GSDMD.Oxidative medicine and cellular longevity · 2022Article
- RhoJ facilitates angiogenesis in glioblastoma via JNK/VEGFR2 mediated activation of PAK and ERK signaling pathways.International journal of biological sciences · 2022Article
- Review
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 2 institutions in 1 country.
Junfeng ZhangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Wei XueDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Kai XuDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Liang YiDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yu GuoDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Tian XieDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Haipeng TongDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Bo ZhouDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Shunan WangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Qing LiDepartment of Oncology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Heng LiuDepartment of Radiology, PLA Rocket Force Characteristic Medical Center, Beijing, 100088, China.
Xiao ChenDepartment of Nuclear Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Jingqin FangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Weiguo ZhangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Daping Hospital · CNArmy Medical University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
AnimalsAntineoplastic Combined Chemotherapy ProtocolsApoptosisBevacizumabBrainBrain NeoplasmsCell Line, TumorCell ProliferationDrug SynergismGlioblastomaHumansHuman Umbilical Vein Endothelial CellsLactic AcidMaleMiceMultiparametric Magnetic Resonance Imaging3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-oneBevacizumabLactic AcidPFKFB3 protein, humanPhosphofructokinase-2PyridinesVascular Endothelial Growth Factor AVEGFA protein, humanbevacizumabglioblastomaMRIPFKFB3tumor vascular normalization
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.