Evidence map›Paper›PMID 32641988›Full record

ArticleTheranostics2020

Ultrafast three-dimensional microbubble imaging

Ryan M Jones, Dallan McMahon, Kullervo Hynynen

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cardiac gene delivery using ultrasound: State of the field.Molecular therapy. Methods & clinical development · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Passive Cavitation Imaging Artifact Reduction Using Data-Adaptive Spatial Filtering.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023
    Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ryan M JonesPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Dallan McMahonPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Kullervo HynynenPhysical Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada.
Sunnybrook Research InstituteUniversity of Toronto · CA

Funding

Ultrasound Therapy Delivery Through Intact SkullR01EB003268 · NIBIB · SUNNYBROOK & WOMEN'S COLL HLTH SCIS CTR · PI HYNYNEN, KULLERVO · 2003 to 2020
$8.2M
NIBIB NIH HHS R01 EB003268
6 · The paper itself

Abstract

Transcranial magnetic resonance imaging (MRI)-guided focused ultrasound (FUS) thermal ablation is under clinical investigation for non-invasive neurosurgery, though its use is restricted to central brain targets due primarily to skull heating effects. The combination of FUS and contrast agent microbubbles greatly reduces the ultrasound exposure levels needed to ablate brain tissue and may help facilitate the use of transcranial FUS ablation throughout the brain. However, sources of variability exist during microbubble-mediated FUS procedures that necessitate the continued development of systems and methods for online treatment monitoring and control, to ensure that excessive and/or off-target bioeffects are not induced from the exposures.

Indexed as

AnimalsBrainContrast MediaDisease Models, AnimalFeasibility StudiesHigh-Intensity Focused Ultrasound AblationHumansIntraoperative ComplicationsMagnetic Resonance ImagingMaleMicrobubblesMultimodal ImagingNeurosurgical ProceduresPredictive Value of TestsRabbitsTime FactorsContrast Mediafocused ultrasoundimage-guided therapymicrobubble contrast agentsnonthermal ablationultrafast 3D acoustic imaging

Identifiers

PMID32641988
PMCPMC7330857
OpenAlexW3035354418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.