ArticleNature physics2020
The role of single cell mechanical behavior and polarity in driving collective cell migration.
Article in Nature physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 183 citations in OpenAlex.
- Three-dimensional reconfigurable magnetic microswarms with boundary-transcending capabilities.Science advances · 2026Article
- Shape-independent fluidity in epithelial cell monolayers.Nature communications · 2026Article
- Geometric programming of asymmetric colloidal dynamics via topological defect reconfiguration.Nature communications · 2026Article
- Controlling tissue size by active fracture.Physical review. E · 2026Article
- Functionally Graded Surfaces and Materials: From Fabrication to Biomedical Applications.Chemical reviews · 2026Review
- Selecting the optimal cell migration assay: fundamentals and practical guidelines.Nature methods · 2026Review
- Accessible and cost-effective methods for patterning cell monolayers on compliant substrates.PloS one · 2026Article
- Article
- Collective migration modes in development, tissue repair and cancer.Nature reviews. Molecular cell biology · 2025Review
- Article
- Tissue geometry and mechanochemical feedback initiate rotational migration inbioRxiv : the preprint server for biology · 2025Article
- Shaping epithelial tissues by stem cell mechanics in development and cancer.Nature reviews. Molecular cell biology · 2025Review
- 3D hydrogel platform with macromolecular actuators for precisely controlled mechanical forces on cancer cell migration.Nature communications · 2025Article
- Flocking and giant fluctuations in epithelial active solids.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Electrotaxis disrupts patterns of cell-cell interactions of human corneal epithelial cells in vitro.Biophysical journal · 2025Article
- Review
- Global versus local matrix remodeling drives rotational versus invasive collective migration of epithelial cells.Developmental cell · 2025Article
- Divergence in cellular markers observed in single-cell transcriptomics datasets between cultured primary trabecular meshwork cells and tissues.Scientific data · 2025Article
- Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 3 countries.
Funding
Abstract
The directed migration of cell collectives is essential in various physiological processes, such as epiboly, intestinal epithelial turnover, and convergent extension during morphogenesis as well as during pathological events like wound healing and cancer metastasis. Collective cell migration leads to the emergence of coordinated movements over multiple cells. Our current understanding emphasizes that these movements are mainly driven by large-scale transmission of signals through adherens junctions. In this study, we show that collective movements of epithelial cells can be triggered by polarity signals at the single cell level through the establishment of coordinated lamellipodial protrusions. We designed a minimalistic model system to generate one-dimensional epithelial trains confined in ring shaped patterns that recapitulate rotational movements observed
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.