ArticleJournal of exercise science and fitness2020
The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial.
Article in Journal of exercise science and fitness, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 5 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Effects of Different Training Modalities on Circulating Irisin Levels in Overweight and Obesity Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Pooled it
- Pooled it
- Comparison of the Effect of Endurance, Strength and Endurance-Strength Training on Glucose and Insulin Homeostasis and the Lipid Profile of Overweight and Obese Subjects: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Effect of Chronic Resistance Training on Circulating Irisin: Systematic Review and Meta-Analysis of Randomized Controlled Trials.International journal of environmental research and public health · 2021Pooled it
- Effects of Resistance Exercise and Whey Protein Supplementation on Irisin Levels in Patients with MASLD Under a Calorie-Restricted Diet.Nutrients · 2026Trial
- The impact of an integrated exercise and dietary counseling program on physiological biomarkers in sedentary bank employees: a randomized control trial.Scientific reports · 2025Trial
- Comparative efficacy of various exercise therapies for metabolic syndrome a systematic review and network meta-analysis.iScience · 2026Article
- Combined Aerobic and Resistance Exercise Program in Adults: Endocrine and Metabolic Adaptations.Life (Basel, Switzerland) · 2026Article
- Muscle-Tumor Crosstalk in Exercise Oncology: Exercise-Induced Myokines and Cancer Cachexia.Cancers · 2026Review
- Optimal exercise strategies to improve HDL-C in metabolic syndrome: A systematic review with pairwise, network, and dose-response meta-analysis.Journal of sport and health science · 2026Review
- Exercise-Induced Myokines in Obesity-Related Metabolic Disorders and Cardiovascular Protection: A Narrative Review.Sports (Basel, Switzerland) · 2026Review
- Irisin, Brain-Derived Neurotrophic Factor (BDNF), and Redox Balance in Geriatric Dynapenia.Antioxidants (Basel, Switzerland) · 2025Article
- High-intensity training and irisin response: A possible molecular cross-talk for irisin response.Current research in physiology · 2025Review
- The impact of vitamin D on type 2 diabetes management: boosting PTP1B gene expression and physical activity benefits in rats.Genes & nutrition · 2024Article
- The therapeutic potential of irisin to mitigate the risk of metabolic syndrome in postmenopausal women.Frontiers in reproductive health · 2024Review
- The Effect of Exercise Training on Irisin Secretion in Patients with Type 2 Diabetes: A Systematic Review.Journal of clinical medicine · 2022Review
- Review
- Comparison irisin peptide serum level in pregnant women with and without gestational diabetes mellitus: A case-control study.Endocrinology, diabetes & metabolism · 2022Article
- The Effects of Different Types of Exercise on Circulating Irisin Levels in Healthy Individuals and in People With Overweight, Metabolic Syndrome and Type 2 Diabetes.Physiological research · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveIrisin is suggested to be an exercise beneficial effects mediator. This study aimed to examine the effects of the aerobic exercise (AE), resistance exercise (RE), and combined exercise (CE) on the plasma levels of irisin and some metabolic and anthropometric indices.
methodsSixty overweight women with metabolic syndrome were assigned equally into four groups: AE, RE, CE, and control. The study variables were measured before and 24 h after the intervention period.
resultsNone of the study groups showed statistically significant changes in the serum irisin. However, muscle mass significantly increased in the RE and CE groups. Also, a significant decrease was observed in the body fat percentage in all groups. In addition, compared with the control group, the homeostatic model assessment of insulin resistance in the AE (p = 0.021), RE (p = 0.039), and in the CE (p = 0.003) groups reduced significantly. According to the analysis of indices' changes, serum irisin was significantly correlated with the body fat percentage (r = 0.532) and HOMA-IR (r = 0.424).
conclusionsThe systematic exercise program for 8-weeks did not change circulating irisin and no statistically significant difference was observed between the exercise methods. Also, serum irisin seemed to be associated with the glycemic status, body fat and weight independent of exercise activity. RCT REGISTRATION CODE: IRCT20180806040721N2. REGISTRY NAME: Iranian Registry of Clinical Trials.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.