ArticleNature2020
Glucose metabolism links astroglial mitochondria to cannabinoid effects.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
27.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it, 254 citations in OpenAlex.
- Cannabinoids Drugs and Oral Health-From Recreational Side-Effects to Medicinal Purposes: A Systematic Review.International journal of molecular sciences · 2021Pooled it
- Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Acute Cannabis Administration Transiently Reduces Mitochondrial DNA in Young Adults: Findings from a Secondary Analysis of a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.Cannabis and cannabinoid research · 2025Trial
- The endocannabinoid system and the ageing brain.Nature reviews. Neuroscience · 2026Review
- Transcriptional and epigenetic regulation of the cannabinoid receptor type-1 (CB1R) in health and disease: an overview.Pharmacological reports : PR · 2026Review
- Neurotoxicity of Synthetic Cannabinoid Receptor Agonist Cumyl-PINACA: An In Vitro Study on Rat Cortical Neurons and Astrocytes.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Roles of lactate and protein lactylation in neurogenesis and neurodegenerative disease.Journal of translational medicine · 2026Review
- Brain mitochondria as key drivers of cognition and behaviour.Nature reviews. Neuroscience · 2026Review
- A transient mitochondrial switch underlies long lasting effects of adolescent cannabis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Metabolic crosstalk in the ageing brain: astrocyte-neuron coupling as a target for homeostatic restoration and therapy.Translational neurodegeneration · 2026Review
- Inhibition of endocannabinoid degradation in astrocytes reprograms glial reactivity and prevents seizure sequelae.Journal of neuroinflammation · 2026Article
- Astrocytic GPR55 receptors promote glycolysis.Journal of cannabis research · 2026Article
- Propofol Attenuates Brain Ischemic Injury Through the Cannabinoid Type 1 (CB1) Receptor.Cureus · 2026Article
- Adult Rat Offspring Exposed to THC during Gestation Exhibit Distinct Biomolecular Changes Identified by X-ray Fluorescence Imaging and Fourier Transform Infrared Spectroscopy in Cortico-Limbic Circuits.ACS chemical neuroscience · 2026Article
- Astrocyte CBJournal of neuroinflammation · 2026Article
- Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026Review
- Roles of Oxidative Phosphorylation and Fatty Acid Oxidation in Neuroinflammation Induced by Lipopolysaccharide in Hypothalamic Neuronal Cells.International journal of inflammation · 2026Article
- Astrocytes in Parkinson's Disease: From Guardians to Accomplices.Clinical interventions in aging · 2026Review
- Chronic Stress and Astrocyte Dysfunction in Depression: Molecular Mechanisms and Gene Expression Changes.Antioxidants (Basel, Switzerland) · 2025Review
- Cannabinoid Ligand-Mediated Glycogen Depletion in Astrocytes Is Associated With Increased Intracellular Calcium, Energy Metabolism, and Membrane Dynamics.Journal of neurochemistry · 2025Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 8 institutions in 6 countries.
Daniel Jimenez-Blasco *Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-1384-1832
Arnau Busquets-Garcia *INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.ORCID http://orcid.org/0000-0002-7100-8873
Etienne Hebert-Chatelain *Canada Research Chair in Mitochondrial Signaling and Physiopathology, Université de Moncton, Moncton, New Brunswick, Canada.
Roman SerratINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Carlos Vicente-GutierrezInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-6481-595X
Christina IoannidouINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.ORCID http://orcid.org/0000-0003-2726-0403
Paula Gómez-SotresINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Irene Lopez-FabuelInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0002-3049-748X
Monica Resch-BeusherInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.
Eva ReselInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación Neuroquímica (IUIN) and Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.
Dorian ArnouilINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Dave SaraswatINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Marjorie VarilhINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Astrid CannichINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Francisca Julio-KalajzicINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Itziar Bonilla-Del RíoDepartment of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.
Angeles AlmeidaInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.
Nagore PuenteDepartment of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.
Svein AchicallendeDepartment of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID http://orcid.org/0000-0002-9245-9761
Maria-Luz Lopez-RodriguezDepartment of Organic Chemistry, Complutense University, Madrid, Spain.
Charlotte JolléDepartment of Physiology, University of Lausanne, Lausanne, Switzerland.
Nicole DéglonDepartment of Clinical Neurosciences, Laboratory of Cellular and Molecular Neurotherapies (LCMN), University of Lausanne, Lausanne, Switzerland.
Luc PellerinDepartment of Physiology, University of Lausanne, Lausanne, Switzerland.
Charlène JosephineUniversité Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.
Gilles BonventoUniversité Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.ORCID http://orcid.org/0000-0002-2886-4228
Aude PanatierINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.ORCID http://orcid.org/0000-0002-6107-4463
Beat LutzInstitute of Physiological Chemistry, University Medical Center, Mainz, Germany.
Pier-Vincenzo PiazzaINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Manuel GuzmánInstituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación Neuroquímica (IUIN) and Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.
Luigi BellocchioINSERM, U1215 NeuroCentre Magendie, Bordeaux, France.
Anne-Karine Bouzier-SoreCentre de Résonance Magnétique des Systèmes Biologiques UMR 5536, CNRS-University of Bordeaux, Bordeaux, France.
Pedro GrandesDepartment of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.
Juan P BolañosInstitute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain. jbolanos@usal.es.ORCID http://orcid.org/0000-0002-3949-6862
Giovanni MarsicanoINSERM, U1215 NeuroCentre Magendie, Bordeaux, France. giovanni.marsicano@inserm.fr.ORCID http://orcid.org/0000-0003-3804-1951
Université de Bordeaux · FRUniversidad de Salamanca · ESCentre National de la Recherche Scientifique · FRUniversity of the Basque Country · ESUniversidad Complutense de Madrid · ESUniversity of Lausanne · CHJohannes Gutenberg University Mainz · DEUniversité de Moncton · CA
Funding
European Research CouncilNIH HHS 1R21DA037678-01
Abstract
Astrocytes take up glucose from the bloodstream to provide energy to the brain, thereby allowing neuronal activity and behavioural responses
Indexed as
Energy MetabolismAnimalsAstrocytesCannabinoid Receptor AgonistsCells, CulturedDronabinolElectron Transport Complex IGlucoseGlycolysisHumansHypoxia-Inducible Factor 1Lactic AcidMaleMiceMitochondriaMitochondrial MembranesCannabinoid Receptor AgonistsDronabinolElectron Transport Complex IGlucoseHypoxia-Inducible Factor 1Lactic AcidNDUFS4 protein, humanReactive Oxygen SpeciesReceptor, Cannabinoid, CB1
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.