Evidence map›Paper›PMID 32641776›Full record

ArticleCell death and differentiation2020

Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability.

Fabio Bertan, Lena Wischhof, Liudmila Sosulina, Manuel Mittag, Dennis Dalügge, Alessandra Fornarelli, Fabrizio Gardoni, Elena Marcello, Monica Di Luca, Martin Fuhrmann and 3 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Cell death and differentiation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. CRISPR/Cas9-mediatedFrontiers in physiology · 2026
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  7. Whole exome sequencing revealed ultra-rare genetic variations in juvenile myoclonic epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  8. Article
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  10. Review
  11. Review
  12. Article
  13. Emerging Antiarrhythmic Drugs for Atrial Fibrillation.International journal of molecular sciences · 2022
    Review
  14. Article
  15. Review
  16. Review
  17. RyR-mediated CaProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Article
  19. CaCells · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Fabio Bertan *German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-7781-5094
Lena Wischhof *German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Liudmila Sosulina *German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Manuel Mittag *German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Dennis DalüggeGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Alessandra FornarelliGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Fabrizio GardoniDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Elena MarcelloDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.ORCID http://orcid.org/0000-0003-0452-762X
Monica Di LucaDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
Martin FuhrmannGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Stefan RemyGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Daniele BanoGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID http://orcid.org/0000-0002-9617-5504
Pierluigi NicoteraGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. pierluigi.nicotera@dzne.de.
German Center for Neurodegenerative Diseases · DEUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dendritic spines are postsynaptic domains that shape structural and functional properties of neurons. Upon neuronal activity, Ca

Indexed as

AnimalsDendritic SpinesFemaleHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutNeuronal PlasticityPyramidal CellsRyanodine Receptor Calcium Release ChannelSynapsesryanodine receptor 2. mouseRyanodine Receptor Calcium Release Channel

Identifiers

PMID32641776
PMCPMC7853040
OpenAlexW4205933412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.