Evidence map›Paper›PMID 32641658›Full record

ArticleInternal medicine (Tokyo, Japan)2020

Continued Aspirin Treatment May Be a Risk Factor of Delayed Bleeding after Gastric Endoscopic Submucosal Dissection under Heparin Replacement: A Retrospective Multicenter Study.

Kenta Hamada, Hiromitsu Kanzaki, Masafumi Inoue, Shuhei Ishiyama, Kenji Yamauchi, Koji Miyahara, Tatsuya Toyokawa, Takao Tsuzuki, Jiro Miyaike, Minoru Matsubara and 10 more

Open access · diamondAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 16 institutions in 1 country.

Kenta HamadaDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Hiromitsu KanzakiDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Masafumi InoueDepartment of Gastroenterology, Japanese Red Cross Okayama Hospital, Japan.
Shuhei IshiyamaDepartment of Internal Medicine, Okayama Saiseikai General Hospital, Japan.
Kenji YamauchiDepartment of Gastroenterology, Mitoyo General Hospital, Japan.
Koji MiyaharaDepartment of Internal Medicine, Hiroshima City Hospital, Japan.
Tatsuya ToyokawaDepartment of Gastroenterology, National Hospital Organization Fukuyama Medical Center, Japan.
Takao TsuzukiDepartment of Internal Medicine, Japanese Red Cross Society Himeji Hospital, Japan.
Jiro MiyaikeDepartment of Internal Medicine, Saiseikai Imabari Hospital, Japan.
Minoru MatsubaraDepartment of Internal Medicine, Sumitomo Besshi Hospital, Japan.
Sakuma TakahashiDepartment of Gastroenterology, Kagawa Prefectural Central Hospital, Japan.
Mamoru NishimuraDepartment of Internal Medicine, Okayama City Hospital, Japan.
Ryuta TakenakaDepartment of Internal Medicine, Tsuyama Chuo Hospital, Japan.
Naoko YunokiDepartment of Internal Medicine, Akaiwa Medical Association Hospital, Japan.
Shinichiro HoriDepartment of Endoscopy, National Hospital Organization Shikoku Cancer Center, Japan.
Sayo KobayashiDepartment of Internal Medicine, Fukuyama City Hospital, Japan.
Yasushi YamasakiDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Yoshiro KawaharaDepartment of Endoscopy, Okayama University Hospital, Japan.
Hideki IshikawaDepartment of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Japan.
Hiroyuki OkadaDepartment of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Okayama University · JPFukuyama City Hospital · JPHimeji Red Cross Hospital · JPJapan Medical Association · JPKagawa Prefectural Central Hospital · JPKyoto Prefectural University of Medicine · JPMito Saiseikai General Hospital · JPNational Hospital Organization · JPOkayama Prefecture · JPOkayama Red Cross General Hospital · JPOkayama Saiseikai General Hospital · JPOkayama University Hospital · JPSaiseikai Ibaraki Hospital · JPShikoku Cancer Center · JPSumitomo Besshi Hospital · JPTsuyama Chuo Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective Gastric endoscopic submucosal dissection (ESD) under heparin replacement (HR) of warfarin reportedly has a high risk of delayed bleeding (24-57%). It is possible that the delayed bleeding risk may have changed over the years. We evaluated the current risk of delayed bleeding after gastric ESD under HR of anticoagulant agents. Methods We retrospectively reviewed the delayed bleeding rate and analyzed the risk factors for delayed bleeding. Patients Consecutive patients who underwent gastric ESD under HR of anticoagulant agents from July 2015 to June 2017. Results A total of 32 patients with a solitary early gastric cancer and taking anticoagulant agents were analyzed, including 24 patients on warfarin (the warfarin group) and 8 patients on direct oral anticoagulants (the DOAC group). Three (9.4%) patients experienced delayed bleeding: three (12.5%) patients in the warfarin group and no patients in the DOAC group. Continued aspirin treatment was identified to be a risk factor of delayed bleeding (p=0.01). Conclusion Careful management may be required for patients undergoing gastric ESD under continued aspirin treatment in addition to HR of anticoagulant agents; although the delayed bleeding risk after gastric ESD under HR of anticoagulant agents might have decreased over the years.

Indexed as

AgedAged, 80 and overAnticoagulantsAspirinEndoscopic Mucosal ResectionFemaleHeparinHumansJapanMalePostoperative HemorrhageRetrospective StudiesRisk FactorsStomach NeoplasmsWarfarinAnticoagulantsAspirinHeparinWarfarinanticoagulant agentbleedingendoscopic submucosal dissectiongastric cancerheparin replacementwarfarin

Identifiers

PMID32641658
PMCPMC7691037
OpenAlexW3039460588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.