ArticleProceedings of the National Academy of Sciences of the United States of America2020
L-type Ca
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A Reappraisal of the Effects of L-type CaFunction (Oxford, England) · 2023Pooled it
- Research progress on the role and mechanism of STIM and Orai protein-mediated store-operated calcium entry in cardiovascular diseases.Channels (Austin, Tex.) · 2026Review
- The ubiquitin-activating enzyme inhibitor TAK-243 activates store-operated CaBiochimica et biophysica acta. Molecular cell research · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- The CaInternational journal of molecular sciences · 2026Article
- Article
- CALHM5 deficiency alleviates aortic aneurysm by regulating smooth muscle calcium homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- VSMCs and the immune microenvironment: a multidimensional regulatory network driving vascular injury and repair.Frontiers in immunology · 2026Review
- L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure.Clinical and experimental hypertension (New York, N.Y. : 1993) · 2025Article
- Molecular mechanisms and intervention approaches of heart failure (Review).International journal of molecular medicine · 2025Review
- Alantolactone mitigates the elevation of blood pressure in mice induced by angiotensin II by inhibiting calcium channel activation.BMC cardiovascular disorders · 2025Article
- The role and mechanism of vascular wall cell ion channels in vascular fibrosis remodeling.Channels (Austin, Tex.) · 2024Review
- The Reappraisal of the Reappraisal-CRAC Channels Are Activated by L-Type CaFunction (Oxford, England) · 2024Article
- Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023Review
- How Do We Clean Up the Scientific Record?Function (Oxford, England) · 2023Article
- Overcoming Confounding to Characterize the Effects of Calcium Channel Blockers.Function (Oxford, England) · 2023Article
- Mechanisms of Vascular CaHandbook of experimental pharmacology · 2023Article
- cGAS-STING Pathway Performance in the Vulnerable Atherosclerotic Plaque.Aging and disease · 2022Article
- Control of STIM and Orai function by post-translational modifications.Cell calcium · 2022Review
- STIMulating blood pressure.eLife · 2022Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
- Erratum issued
Authors and funding
14 authors at 3 institutions in 2 countries.
Martin T JohnsonDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
Aparna GudlurDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA 92037.
Xuexin ZhangDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.ORCID 0000-0001-8276-3885
Ping XinDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
Scott M EmrichDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
Ryan E YoastDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
Raphael CourjaretDepartment of Physiology and Biophysics, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.ORCID 0000-0002-0042-0377
Robert M NwokonkoDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
Wei LiDepartment of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.ORCID 0000-0001-5696-4309
Nadine HempelPenn State Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
Khaled MachacaDepartment of Physiology and Biophysics, Weill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.ORCID 0000-0001-6215-2411
Donald L GillDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033.
Patrick G HoganDivision of Signaling and Gene Expression, La Jolla Institute for Immunology, La Jolla, CA 92037.ORCID 0000-0001-9869-0684
Mohamed TrebakDepartment of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033; mtrebak@psu.edu.ORCID 0000-0001-6759-864X
Pennsylvania State University · USLa Jolla Institute for Immunology · USWeill Cornell Medical College in Qatar · QA
Funding
SIGNAL TRANSDUCTION AND GENE INDUCTION IN T LYMPHOCYTESR01AI040127 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK, RAO, ANJANA · 1996 to 2025
$13.3MCa2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4MSTIM-ORAI signaling and other calcium influx pathways in lymphocytesR01AI084167 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI HOGAN, PATRICK · 2009 to 2019
$4.9MNRSA Training CoreTL1TR002016 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI THOMAS, GAIL D. · 2016 to 2025
$3.4MUnderstanding Store-Operated Calcium Signal TransductionR35GM131916 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GILL, DONALD L · 2019 to 2023
$2.9MThe Mitochondrial Sodium/Calcium Exchanger (NCLX) in Airway Smooth Muscle Remodeling during AsthmaF30HL147489 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JOHNSON, MARTIN T · 2019 to 2022
$149kNCATS NIH HHS TL1 TR002016NHLBI NIH HHS F30 HL147489NHLBI NIH HHS R35 HL150778NIAID NIH HHS R01 AI040127NIAID NIH HHS R01 AI084167NIGMS NIH HHS R35 GM131916
Abstract
Voltage-gated L-type Ca
Indexed as
AnimalsAntihypertensive AgentsCalciumCalcium Channels, L-TypeCell MembraneCell MovementCell ProliferationDisease Models, AnimalEndoplasmic ReticulumGene Knockout TechniquesHeart FailureHEK293 CellsHumansHypertensionMembrane ProteinsMyocytes, Smooth MuscleAntihypertensive AgentsCalciumCalcium Channels, L-TypeL-type calcium channel alpha(1C)Membrane ProteinsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanSTIM2 protein, humanStromal Interaction Molecule 1Stromal Interaction Molecule 2Stromal Interaction Moleculescalcium signalingCav1.2hypertensionSTIM1vascular remodeling
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.