Evidence map›Paper›PMID 32641497›Full record

ArticleThe Journal of biological chemistry2020

A functional role for eicosanoid-lysophospholipids in activating monocyte signaling.

Gao-Yuan Liu, Sung Ho Moon, Christopher M Jenkins, Harold F Sims, Shaoping Guan, Richard W Gross

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Gao-Yuan LiuDepartment of Chemistry, Washington University, Saint Louis, Missouri, USA; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Sung Ho MoonDivision of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Christopher M JenkinsDivision of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Harold F SimsDivision of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Shaoping GuanDivision of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA.
Richard W GrossDepartment of Chemistry, Washington University, Saint Louis, Missouri, USA; Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA; Developmental Biology, Washington University School of Medicine, Saint Louis, Missouri, USA; Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, Saint Louis, Missouri, USA. Electronic address: rgross@wustl.edu.
Washington University in St. Louis · US

Funding

REGULATION OF MYOCARDIAL PHOSPHOLIPASES AND LIPASES IN DIABETIC MYOCARDIUMR01HL118639 · NHLBI · WASHINGTON UNIVERSITY · PI GROSS, RICHARD W · 2013 to 2025
$9.1M
NOVEL LIPID 2ND MESSENGERS REGULATING BIOENERGETICS AND SIGNALING IN HUMAN MYOCARDIUMR01HL133178 · NHLBI · WASHINGTON UNIVERSITY · PI GROSS, RICHARD W · 2016 to 2024
$3.8M
NHLBI NIH HHS R01 HL118639NHLBI NIH HHS R01 HL133178
6 · The paper itself

Abstract

Recently, eicosanoid-lysophospholipids were identified as novel metabolites generated from the direct cyclooxygenase- or lipoxygenase-catalyzed oxidation of 2-arachidonoyl-lysophospholipids produced from either phospholipase A

Indexed as

Signal TransductionAnimalsCyclooxygenase 1HumansLysophosphatidylcholinesMiceMonocytesTHP-1 CellsTranscription Factor RelATumor Necrosis Factor-alphaCyclooxygenase 1LysophosphatidylcholinesPTGS1 protein, humanRELA protein, humanRela protein, mouseTranscription Factor RelATumor Necrosis Factor-alpha12(S)-HETEcytokineinflammationiPLA2γlysophospholipidNFκBoxidized lysophospholipidsphosphorylation

Identifiers

PMID32641497
PMCPMC7443508
OpenAlexW3041623442

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.