Evidence map›Paper›PMID 32641487›Full record

ArticleScience translational medicine2020

Gut microbiota dysbiosis and altered tryptophan catabolism contribute to autoimmunity in lupus-susceptible mice.

Seung-Chul Choi, Josephine Brown, Minghao Gong, Yong Ge, Mojgan Zadeh, Wei Li, Byron P Croker, George Michailidis, Timothy J Garrett, Mansour Mohamadzadeh and 1 more

Open access · greenAbstract read
In one paragraph

Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 148 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 1 pooled it
10.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 1 synthesis or guideline pooled it, 250 citations in OpenAlex.

  1. Pooled it
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  18. Gut microbes · 2025
    Article
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88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Seung-Chul ChoiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-6230-9087
Josephine BrownDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-2511-8756
Minghao GongDepartment of Infectious Diseases and Immunology, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-1307-7368
Yong GeDepartment of Infectious Diseases and Immunology, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-5967-3857
Mojgan ZadehDepartment of Infectious Diseases and Immunology, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-0407-0359
Wei LiDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0001-9835-8470
Byron P CrokerDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-1670-0493
George MichailidisDepartment of Statistics and the Informatics Institute, University of Florida, Gainesville, FL 32610, USA.
Timothy J GarrettDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0003-1623-009X
Mansour MohamadzadehDepartment of Infectious Diseases and Immunology, University of Florida, Gainesville, FL 32610, USA. morel@ufl.edu m.zadeh@ufl.edu.ORCID 0000-0003-0407-0359
Laurence MorelDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA. morel@ufl.edu m.zadeh@ufl.edu.ORCID 0000-0002-6622-1290
University of Florida · US

Funding

Bacterial surface layer-specific immune protection against gut microbial infectionR01DK109560 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZADEH, MANSOUR M · 2016 to 2024
$3.5M
Gut dysbiosis and tryptophan metabolism in lupusR01AI143313 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Laurence Morel, Gregg Joshua Silverman · 2019 to 2026
$3.3M
Gut dysbiosis induces lupusR21AI122338 · NIAID · UNIVERSITY OF FLORIDA · PI MOREL, LAURENCE · 2016 to 2017
$410k
NIAID NIH HHS R01 AI143313NIAID NIH HHS R21 AI122338NIDDK NIH HHS R01 DK109560
6 · The paper itself

Abstract

The autoimmune disease systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies. It has been postulated that gut microbial dysbiosis may be one of the mechanisms involved in SLE pathogenesis. Here, we demonstrate that the dysbiotic gut microbiota of triple congenic (TC) lupus-prone mice (B6.

Indexed as

Gastrointestinal MicrobiomeLupus Erythematosus, SystemicAnimalsAutoimmunityDysbiosisMiceMice, Inbred C57BLTryptophanTryptophan

Identifiers

PMID32641487
PMCPMC7739186
OpenAlexW3041219042

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.