Evidence map›Paper›PMID 32641485›Full record

ArticleJournal of virology2020

Subclinical Cytomegalovirus and Epstein-Barr Virus Shedding Is Associated with Increasing HIV DNA Molecular Diversity in Peripheral Blood during Suppressive Antiretroviral Therapy.

Antoine Chaillon, Masato Nakazawa, Stephen A Rawlings, Genevieve Curtin, Gemma Caballero, Brianna Scott, Christy Anderson, Sara Gianella

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. HIV reservoirs in lymphomagenesis: hidden driver in the era of viral suppression?Microbiology and molecular biology reviews : MMBR · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Antoine ChaillonUniversity of California, San Diego, La Jolla, California, USA.ORCID 0000-0001-9490-3857
Masato NakazawaUniversity of California, San Diego, La Jolla, California, USA.
Stephen A RawlingsUniversity of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-3637-1447
Genevieve CurtinUniversity of California, San Diego, La Jolla, California, USA.
Gemma CaballeroUniversity of California, San Diego, La Jolla, California, USA.
Brianna ScottUniversity of California, San Diego, La Jolla, California, USA.
Christy AndersonUniversity of California, San Diego, La Jolla, California, USA.
Sara GianellaUniversity of California, San Diego, La Jolla, California, USA gianella@ucsd.edu.ORCID 0000-0002-9927-0849
University of California San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
VirologyP30AI036214 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Maile Ann Young Karris · 1994 to 2026
$78.4M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
HOPE Training GrantT32AI007384 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Sara Gianella Weibel, Scott L Letendre · 1990 to 2026
$9.7M
Revealing Reservoirs during Rebound (R3)P01AI131385 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEIBEL, NADIR · 2017 to 2021
$8.7M
Mechanisms of CMV Replication on HIV PersistenceR01AI147821 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2020 to 2024
$3.2M
The HIV-associated Opioid Micro-Environment (HOME) ProjectDP2DA051915 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2020 to 2020
$2.4M
Effect of Declining Sex Hormones on HIV persistence in HIV Infected Women on ARTR21HD094646 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2017 to 2018
$441k
The Prostate as a Reservoir for Residual ReplicationR21AI131971 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHAILLON, ANTOINE · 2018 to 2019
$432k
Effect of Sex Hormones on HIV persistenceR21AI134295 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GIANELLA WEIBEL, SARA · 2017 to 2018
$426k
NCATS NIH HHS UL1 TR001442NIAID NIH HHS P01 AI131385NIAID NIH HHS P30 AI036214NIAID NIH HHS R01 AI147821NIAID NIH HHS R21 AI131971NIAID NIH HHS R21 AI134295NICHD NIH HHS R21 HD094646NIDA NIH HHS DP2 DA051915NIMH NIH HHS P30 MH062512
6 · The paper itself

Abstract

Cytomegalovirus (CMV) almost universally infects persons with HIV (PWH), and it is a driver of persistent inflammation and HIV persistence. The mechanisms underlying the association between CMV (and possibly other herpesviruses) and HIV persistence are unclear. Serially collected blood samples were obtained from men who have sex with men (MSM) who started antiretroviral therapy (ART) within 1 year of their estimated date of HIV infection (EDI). Total CMV and Epstein-Barr virus (EBV) DNA were quantified in peripheral blood mononuclear cells by droplet digital PCR (ddPCR). Deep sequencing of the HIV DNA partial

Indexed as

Anti-Retroviral AgentsCoinfectionCytomegalovirusCytomegalovirus InfectionsDNA, ViralEpstein-Barr Virus InfectionsHerpesvirus 4, HumanHIV-1HIV InfectionsHomosexuality, MaleHumansMaleRNA, ViralVirus SheddingAnti-Retroviral AgentsDNA, ViralRNA, ViralcytomegalovirusEpstein-Barr virusHIV reservoir

Identifiers

PMID32641485
PMCPMC7495390
OpenAlexW3040970081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.