Evidence map›Paper›PMID 32641480›Full record

ArticleJournal of virology2020

Reactivation of Epstein-Barr Virus by HIF-1α Requires p53.

Richard J Kraus, Blue-Leaf A Cordes, Saraniya Sathiamoorthi, Parita Patel, Xueying Yuan, Tawin Iempridee, Xianming Yu, Denis L Lee, Paul F Lambert, Janet E Mertz

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Chromatin Control of EBV Infection and Latency.Current topics in microbiology and immunology · 2025
    Article
  7. Viral oncogenesis in cancer: from mechanisms to therapeutics.Signal transduction and targeted therapy · 2025
    Review
  8. Review
  9. Therapeutic opportunities in EBV-positive gastric cancer subtypes.Therapeutic advances in medical oncology · 2025
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Richard J KrausMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Blue-Leaf A CordesMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Saraniya SathiamoorthiMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Parita PatelMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Xueying YuanMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Tawin IemprideeNational Nanotechnology Center, National Science and Technology Development Agency, Pathum Thani, Thailand.
Xianming YuMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Denis L LeeMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Paul F LambertMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA.
Janet E MertzMcArdle Laboratory for Cancer Research, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, USA mertz@oncology.wisc.edu.ORCID 0000-0002-4754-7594
University of Wisconsin–Madison · USNational Science and Technology Development Agency · TH

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Christian Capitini · 1985 to 2026
$142.6M
Visualizing EBV and HCMV DNA Dynamics During InfectionP01CA022443 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI WILLIAM M. SUGDEN · 1985 to 2026
$53.1M
Defining Drivers of HPV-associated CarcinogenesisR35CA210807 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Paul F. Lambert · 2017 to 2026
$9.2M
NCI NIH HHS P01 CA022443NCI NIH HHS P30 CA014520NCI NIH HHS R35 CA210807
6 · The paper itself

Abstract

We previously reported that the cellular transcription factor hypoxia-inducible factor 1α (HIF-1α) binds a hypoxia response element (HRE) located within the promoter of Epstein-Barr virus's (EBV's) latent-lytic switch

Indexed as

Cell Line, TumorCyclopentanesDeferoxamineEnzyme InhibitorsEpithelial CellsGene Expression RegulationGlycineHerpesvirus 4, HumanHost-Pathogen InteractionsHumansHypoxia-Inducible Factor 1, alpha SubunitImidazolesIron Chelating AgentsIsoquinolinesLymphocytesMorpholines2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-oneBZLF1 protein, Herpesvirus 4, HumanCyclopentanesDeferoxamineEnzyme InhibitorsGlycineHIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitImidazolesIron Chelating AgentsIsoquinolinesMorpholinesnutlin 3pevonedistatPiperazinesProlyl-Hydroxylase InhibitorsPyrimidinesPyronesRNA, Small InterferingroxadustatTrans-ActivatorsTumor Suppressor Protein p53BZLF1 gene promoterdeferoxaminehypoxia response elementlatent-lytic switchnutlin-3pevonedistat

Identifiers

PMID32641480
PMCPMC7459560
OpenAlexW3040719247

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.