Evidence map›Paper›PMID 32641474›Full record

ArticleJournal of virology2020

Cell Fusion Induced by a Fusion-Active Form of Human Cytomegalovirus Glycoprotein B (gB) Is Inhibited by Antibodies Directed at Antigenic Domain 5 in the Ectodomain of gB.

Nina Reuter, Barbara Kropff, Julia Karin Schneiderbanger, Mira Alt, Adalbert Krawczyk, Christian Sinzger, Thomas H Winkler, William J Britt, Michael Mach, Marco Thomas

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. A vaccine against cytomegalovirus: how close are we?The Journal of clinical investigation · 2025
    Article
  6. Article
  7. Virus-Induced Cell Fusion and Syncytia Formation.Results and problems in cell differentiation · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Identification and characterization of human cytomegalovirus-encoded circular RNAs.Frontiers in cellular and infection microbiology · 2022
    Article
  13. Characterization ofViruses · 2021
    Article
  14. Article
  15. Review
  16. Diazadispiroalkane Derivatives Are New Viral Entry Inhibitors.Antimicrobial agents and chemotherapy · 2021
    Article
  17. Virus-Mediated Cell-Cell Fusion.International journal of molecular sciences · 2020
    Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Nina ReuterVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Barbara KropffVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Julia Karin SchneiderbangerVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Mira AltInstitut für Virologie, Universitätsklinikum Duisburg-Essen, Essen, Germany.
Adalbert KrawczykInstitut für Virologie, Universitätsklinikum Duisburg-Essen, Essen, Germany.
Christian SinzgerInstitut für Virologie, Universitätsklinikum Ulm, Ulm, Germany.
Thomas H WinklerNikolaus-Fiebiger-Zentrum für Molekulare Medizin, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
William J BrittDepartments of Pediatrics, Microbiology and Neurobiology, Children's Hospital of Alabama, University of Alabama School of Medicine, Birmingham, Alabama, USA.
Michael MachVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
Marco ThomasVirologisches Institut, Klinische und Molekulare Virologie, Friedrich Alexander Universität Erlangen-Nürnberg, Erlangen, Germany Marco.Thomas@uk-erlangen.de.ORCID 0000-0003-4820-2712
Friedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Duisburg-Essen · DEUniversity Hospital Ulm · DEUniversity of Alabama · US

Funding

Congenital CMV and CNS Infection Mechanisms of Protective ImmunityR01AI089956 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI William Jarvis Britt · 2011 to 2026
$7.7M
CMV Vaccines: Reinfection and Antigenic Variation (Vision and auditory screening in infants born to women enrolled in ZIP)R01HD061959 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, MUSSI-PINHATA, MARISA MARCIA · 2011 to 2023
$5.9M
ENVELOPE ASSEMBLY OF HUMAN CYTOMEGALOVIRUSR01AI035602 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS · 1995 to 2018
$4.5M
Identification of pre-fusion conformers of HCMV gBR21AI126886 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BRITT, WILLIAM JARVIS, MACH, MICHAEL · 2016 to 2017
$358k
NIAID NIH HHS R01 AI035602NIAID NIH HHS R01 AI089956NIAID NIH HHS R21 AI126886NICHD NIH HHS R01 HD061959
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that can cause severe clinical disease in allograft recipients and infants infected

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralBinding SitesCell FusionCell LineCytomegalovirusEpithelial CellsFibroblastsGene ExpressionGiant CellsHEK293 CellsHumansMiceMutant Chimeric ProteinsAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, Viralglycoprotein B, Simplexvirusglycoprotein H, CytomegalovirusMutant Chimeric ProteinsUL115 protein, Human herpesvirus 5Viral Envelope Proteinsantibodiescell-cell fusionglycoprotein Bherpesvirushuman cytomegalovirus

Identifiers

PMID32641474
PMCPMC7459561
OpenAlexW3039967352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.