Evidence map›Paper›PMID 32641451›Full record

ArticleG3 (Bethesda, Md.)2020

Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in

Vladimir Vélez-Segarra, Sahily González-Crespo, Ednalise Santiago-Cartagena, Luis E Vázquez-Quiñones, Nelson Martínez-Matías, Yamirelis Otero, Julián J Zayas, Rafael Siaca, Jeanmadi Del Rosario, Inoushka Mejías and 10 more

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Vladimir Vélez-SegarraDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Sahily González-CrespoDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Ednalise Santiago-CartagenaDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Luis E Vázquez-QuiñonesSchool of Science and Technology, University Ana G. Mendez, Cupey Campus, Ana G Mendez Ave, No.1399, San Juan, PR 00926.
Nelson Martínez-MatíasDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Yamirelis OteroDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Julián J ZayasDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Rafael SiacaDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Jeanmadi Del RosarioDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Inoushka MejíasDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
José J AponteDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Noelani C CollazoDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Francisco J LassoDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067.
Jamie SniderDonnelly Centre, Department of Biochemistry, and Department of Molecular Genetics, University of Toronto, Ontario M5S 3E1, Canada.
Matthew JessulatDepartment of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.
Hiroyuki AokiDepartment of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.
Brian C RymondDepartment of Biology, University of Kentucky, Lexington, KY 40506.
Mohan BabuDepartment of Biochemistry, University of Regina, Regina, Saskatchewan S4S 0A2, Canada.
Igor StagljarDonnelly Centre, Department of Biochemistry, and Department of Molecular Genetics, University of Toronto, Ontario M5S 3E1, Canada.
José R Rodríguez-MedinaDepartment of Biochemistry, University of Puerto Rico, Medical Sciences Campus, PO Box 365067, San Juan, PR 00936-067 jose.rodriguez123@upr.edu.
University of Puerto Rico, Medical Sciences Campus · PRUniversity of Regina · CAAna G. Mendez University System · PRMediterranean Institute for Life Sciences · HRUniversity of Kentucky · USUniversity of Toronto · CA

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
Upstream Regulation and Downstream effectors of c-MYC in Ovarian CancerU54MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Souhail M Malave-Rivera · 2017 to 2026
$35.8M
RISE Option III: MBRS RISE at the UPR Medical Sciences CampusR25GM061838 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI CADILLA, CARMEN LYDIA · 2000 to 2021
$25.5M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54MD007587 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI LUCIANO, CARLOS A., WOJNA, VALERIE · 2012 to 2018
$23.2M
Tracking and Evaluation CoreU54GM133807 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI ACOSTA-PEREZ, EDNA · 2020 to 2024
$17.7M
CIHR FDN-154318CIHR MOP-125952CIHR RSN-124512CIHR RSN-132191NIGMS NIH HHS P20 GM103475NIGMS NIH HHS R25 GM061838NIGMS NIH HHS U54 GM133807NIMHD NIH HHS U54 MD007587NIMHD NIH HHS U54 MD007600
6 · The paper itself

Abstract

Antifungal drug discovery and design is very challenging because of the considerable similarities in genetic features and metabolic pathways between fungi and humans. However, cell wall composition represents a notable point of divergence. Therefore, a research strategy was designed to improve our understanding of the mechanisms for maintaining fungal cell wall integrity, and to identify potential targets for new drugs that modulate the underlying protein-protein interactions in

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCell WallFungal ProteinsGene Expression Regulation, FungalHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsFungal ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsSaccharomyces cerevisiae ProteinsWSC2 protein, S cerevisiaeWSC3 protein, S cerevisiaecell wall integrity pathwaymechanosensory proteinsprotein-protein interactionsstress response

Identifiers

PMID32641451
PMCPMC7466973
OpenAlexW3041789487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.