Evidence map›Paper›PMID 32641432›Full record

ArticleJournal of lipid research2020

Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a).

Ayelet Gonen, Xiaohong Yang, Calvin Yeang, Elena Alekseeva, Marlys Koschinsky, Joseph L Witztum, Michael Boffa, Sotirios Tsimikas

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of lipid research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Lipoprotein(a) and cardiovascular disease.The Biochemical journal · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ayelet GonenDivision of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Xiaohong YangVascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Calvin YeangVascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, University of California San Diego, La Jolla, CA, USA.
Elena AlekseevaDivision of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Marlys KoschinskyRobarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada.
Joseph L WitztumDivision of Endocrinology and Metabolism, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Michael BoffaDepartment of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Sotirios TsimikasVascular Medicine Program, Sulpizio Cardiovascular Center, Division of Cardiology, University of California San Diego, La Jolla, CA, USA stsimikas@ucsd.edu.ORCID 0000-0001-9834-9494
University of California San Diego · USWestern University · CA

Funding

Project 4: APOB-specific CD4 and CD8 T cells exacerbate atherosclerosisP01HL136275 · NHLBI · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI Catherine C Hedrick · 2017 to 2026
$25.5M
NHLBI NIH HHS P01 HL136275
6 · The paper itself

Abstract

Lipoprotein (a) [Lp(a)] is a risk factor for CVD and a target of therapy, but Lp(a) measurements are not globally standardized. Commercially available assays generally use polyclonal antibodies that detect multiple sites within the kringle (K)IV

Indexed as

Antibodies, MonoclonalMice, Inbred BALB CAnimalsApolipoproteins ABinding SitesHumansMiceAntibodies, MonoclonalApolipoproteins Aaortic stenosiscardiovascular diseaseisoformkringlelipoprotein (a)lipoprotein (a)-kringle IV9metabolism, therapymonoclonal antibody

Identifiers

PMID32641432
PMCPMC7469883
OpenAlexW3041525889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.