ArticleCancer research2020
Genome-Wide Association Study Data Reveal Genetic Susceptibility to Chronic Inflammatory Intestinal Diseases and Pancreatic Ductal Adenocarcinoma Risk.
Open access · bronzeAbstract read
In one paragraph
Article in Cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Ubiquitin-specific protease 25 ameliorates ulcerative colitis by regulating the degradation of phosphor-STAT3.Cell death & disease · 2025Article
- Inflammatory bowel disease and risk of ophthalmic inflammation-related diseases: a two-sample Mendelian randomization study.International journal of ophthalmology · 2024Article
- Association between Taxonomic Composition of Gut Microbiota and Host Single Nucleotide Polymorphisms in Crohn's Disease Patients from Russia.International journal of molecular sciences · 2023Article
- Context-Specific Determinants of the Immunosuppressive Tumor Microenvironment in Pancreatic Cancer.Cancer discovery · 2023Review
- Autoimmune conditions and pancreatic cancer risk in older American adults.International journal of cancer · 2023Article
- Polymorphisms of TNF-alpha (- 308), IL-1beta (+ 3954) and IL1-Ra (VNTR) are associated to severe stage of endometriosis in Mexican women: a case control study.BMC women's health · 2022Article
- Glycoprotein 2 in health and disease: lifting the veil.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
75 authors at 20 institutions in 10 countries.
Fangcheng YuanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.ORCID 0000-0002-8443-6754
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-4486-7496
Naomi WalshNational Institute for Cellular Biotechnology, Dublin City University, Glasnevin, Dublin, Ireland.ORCID 0000-0002-2178-3564
Han ZhangDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0003-3676-8954
William WheelerInformation Management Services, Inc., Silver Spring, Maryland.
Lei SongDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Alan A ArslanDepartment of Obstetrics and Gynecology, New York University School of Medicine, New York, New York, USA.ORCID 0000-0002-7775-8085
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Paige BracciDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-4261-4583
Mengmeng DuDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
Steven GallingerLunenfeld-Tanenbaum Research Institute, Sinai Health System and University of Toronto, Toronto, Ontario, Canada.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0003-4946-9099
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Loic Le MarchandCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Rachel E NealeDepartment of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Jonas RosendahlDepartment of Internal Medicine I, Martin Luther University, Halle, Germany.
Ghislaine SceloInternational Agency for Research on Cancer, Lyon, France.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Emily WhiteCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Pilar AmianoPublic Health Division of Gipuzkoa, Ministry of Health of the Basque Government, Donostia-San Sebastian, Spain.
Gabriella AndreottiDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Ana BabicDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
William R BamletDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2903-1284
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Paul BrennanInternational Agency for Research on Cancer, Lyon, France.ORCID 0000-0002-0518-8714
Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Julie E BuringDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Charles S FuchsYale Cancer Center, New Haven, Connecticut.
J Michael GazianoDivision of Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Michael G GogginsDepartment of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins School of Medicine, Baltimore, Maryland.
Thilo HackertDepartment of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0002-7012-1196
Patricia HartgeDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Manal M HassanDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Elizabeth A HollyDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Robert N HooverDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Verena KatzkeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6509-6555
Holger KirstenInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID 0000-0002-3126-7950
Robert C KurtzGastroenterology, Hepatology, and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, New York.
I-Min LeeDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Nuria MalatsGenetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre, Madrid, Spain.ORCID 0000-0003-2538-3784
Roger L MilneCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.ORCID 0000-0001-5764-7268
Neil MurphySection of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Kimmie NgDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Ann L ObergDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.ORCID 0000-0003-2539-9807
Miquel PortaCIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Kari G RabeDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Francisco X RealCIBERONC, Madrid, Spain.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Howard D SessoDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Debra T SilvermanDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Ian M ThompsonCHRISTUS Santa Rosa Hospital - Medical Center, San Antonio, Texas.
Jean Wactawski-WendeDepartment of Epidemiology and Environmental Health, University at Buffalo, Buffalo, New York.ORCID 0000-0003-3096-9595
Xiaoliang WangCancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Lynne R WilkensCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Herbert YuCancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.ORCID 0000-0003-3950-4815
Anne Zeleniuch-JacquotteDepartment of Population Health, New York University School of Medicine, New York, New York.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Eric J DuellUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute (IDIBELL), Catalan Institute of Oncology (ICO), Barcelona, Spain.ORCID 0000-0001-5256-0163
Laufey T AmundadottirDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.ORCID 0000-0003-1859-8971
Donghui LiDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0002-7542-0662
Gloria M PetersenDepartment of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota.
Brian M WolpinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
Kai YuDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.ORCID 0000-0003-3950-4815
Alison P KleinDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.ORCID 0000-0003-2737-8399
Rachael Stolzenberg-SolomonDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland. rs221z@nih.gov.ORCID 0000-0003-3698-7006
Center for Cancer Research · USJohns Hopkins University · USBrigham and Women's Hospital · USFred Hutch Cancer Center · USMayo Clinic · USCancer Center of Hawaii · USCentre international de recherche sur le cancer · FRDana-Farber Cancer Institute · USGerman Cancer Research Center · DELunenfeld-Tanenbaum Research Institute · CAMemorial Sloan Kettering Cancer Center · USNew York University · USThe University of Melbourne · AUThe University of Texas MD Anderson Cancer Center · USUniversity of California, San Francisco · USVanderbilt University · USAmerican Cancer Society · USBasque Government · ESChristus Santa Rosa Health System · USDublin City University · IE
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MTranslational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M. · 2004 to 2018
$32.7MCALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MCCR NIH HHS HHSN261200800001CIntramural NIH HHS Z01 CP010193NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261200800001ENCI NIH HHS K07 CA222159NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA006973NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA071789NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA102701NCI NIH HHS R01 CA034944NCI NIH HHS R01 CA040360NCI NIH HHS R01 CA047988NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050706NCI NIH HHS R01 CA054281NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA097075NCI NIH HHS R01 CA097193NCI NIH HHS R01 CA098870NCI NIH HHS R01 CA100967NCI NIH HHS R01 CA109767NCI NIH HHS R01 CA132839NCI NIH HHS R01 CA154823NCI NIH HHS R03 CA123546NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA098758NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA182913NCI NIH HHS U01 CA247283NCI NIH HHS U10 CA037429NCI NIH HHS U24 CA074783NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA182883NCI NIH HHS UM1 CA182913NCI NIH HHS UM1 CA182934NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNHLBI NIH HHS R01 HL026490NHLBI NIH HHS R01 HL034595NHLBI NIH HHS R01 HL043851NHLBI NIH HHS R01 HL080467NHLBI NIH HHS RC1 HL099355NIEHS NIH HHS P30 ES000260World Health Organization 001
Abstract
Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (±500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at
Indexed as
Genetic Predisposition to DiseaseCarcinoma, Pancreatic DuctalCase-Control StudiesCeliac DiseaseCholangitis, SclerosingChronic DiseaseColitis, UlcerativeCrohn DiseaseGenome-Wide Association StudyHumansInflammatory Bowel DiseasesPancreatic NeoplasmsPancreatitis, Chronic
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.