Evidence map›Paper›PMID 32641374›Full record

Trial reportDiabetes care2020

The Association Between HbA

Shilan Seyed Ahmadi, Klara Westman, Aldina Pivodic, Arndís F Ólafsdóttir, Sofia Dahlqvist, Irl B Hirsch, Jarl Hellman, Magnus Ekelund, Tim Heise, William Polonsky and 3 more

Open access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Guideline
  5. Trial
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Shilan Seyed AhmadiDepartment of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden shilan.seyed.ahmadi@vgregion.se.
Klara WestmanDepartment of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden.ORCID 0000-0001-6970-2877
Aldina PivodicStatistiska Konsultgruppen, Gothenburg, Sweden.
Arndís F ÓlafsdóttirDepartment of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden.
Sofia DahlqvistDepartment of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden.ORCID 0000-0002-2083-2512
Irl B HirschDivision of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, WA.
Jarl HellmanDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0003-1675-8417
Magnus EkelundType 1 Diabetes & Functional Insulins, Novo Nordisk A/S, Søborg, Denmark.
Tim HeiseProfil, Neuss, Germany.
William PolonskyDepartment of Medicine, University of California, San Diego, La Jolla, CA.
Magnus WijkmanDepartment of Internal Medicine and Department of Health, Medicine and Caring Sciences, Linköping University, Norrköping, Sweden.ORCID 0000-0001-9064-6144
Erik SchwarczDepartment of Medicine, Örebro University Hospital, Örebro, Sweden.
Marcus LindDepartment of Medicine, NU-Hospital Group, Trollhättan/Uddevalla, Sweden.ORCID 0000-0002-3796-9283
NU Hospital Group · SELinköping University · SENovo Nordisk (Denmark) · DKÖrebro University Hospital · SEProfil Institute for Metabolic Research · DEUniversity of California San Diego · USUniversity of Gothenburg · SEUniversity of Washington · USUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAccording to recent guidelines, individuals with type 1 diabetes should spend <4.0% of time per day with glucose levels <3.9 mmol/L (<70 mg/dL) and <1.0% per day with glucose levels <3.0 mmol/L (<54 mg/dL). RESEARCH DESIGN AND

methodsIn the GOLD randomized crossover trial, 161 individuals with type 1 diabetes treated with multiple daily insulin injections (MDI) were randomized to continuous glucose monitoring (CGM) or conventional therapy with self-monitoring of blood glucose (SMBG) and evaluated over 16 months. We estimated the association between time spent in hypoglycemia and various mean glucose and HbA

resultsTime spent in hypoglycemia (<3.9 mmol/L and <3.0 mmol/L) increased significantly with lower mean HbA

conclusionsReaching current targets for time in hypoglycemia while at the same time reaching HbA

Indexed as

AdultBlood GlucoseBlood Glucose Self-MonitoringCross-Over StudiesDiabetes Mellitus, Type 1Drug Administration ScheduleFemaleGlycated HemoglobinHumansHypoglycemiaInjections, SubcutaneousInsulinMaleMiddle AgedSwedenTime FactorsBlood GlucoseGlycated HemoglobinInsulin

Identifiers

PMID32641374
PMCPMC7440892
OpenAlexW3041249421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.