Evidence map›Paper›PMID 32641315›Full record

ArticleBMJ case reports2020

Effect of autologous adipose-derived mesenchymal stem cell therapy in the treatment of an osteochondral lesion of the ankle.

Julien Freitag, James Wickham, Kiran Shah, Abi Tenen

Registry-linked trialOpen access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04998162 (SVF in Infiltrative Therapy for Ankle Osteoarthritis), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04998162 nacompletednot on this mapstarted 2022, after this paper: background citation

SVF in Infiltrative Therapy for Ankle Osteoarthritis: A Pilot Study

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2022 to 2024Enrolled30ConditionsAnkle OsteoarthritisArmsSVF injection
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Julien FreitagMelbourne Stem Cell Centre, Box Hill North, Victoria, Australia julien.freitag@mscc.com.au.ORCID http://orcid.org/0000-0001-6701-4368
James WickhamSchool of Biomedical Sciences, Charles Sturt University - Orange Campus, Orange, New South Wales, Australia.
Kiran ShahMagellan Stem Cells, Box Hill North, Victoria, Australia.
Abi TenenMelbourne Stem Cell Centre, Box Hill North, Victoria, Australia.
Charles Sturt University · AUStem Cells Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteochondral lesions (OCLs) of the talus are rare but can be associated with significant morbidity and may lead to the development of osteoarthritis. An improved understanding of the action of mesenchymal stem cells (MSCs) has seen renewed interest in their role in cartilage repair, with early preclinical and clinical research showing benefits in symptomatic and structural improvement. A 42-year-old man presented with an unstable OCL of the talus and onset of early osteoarthritis with a history of multiple previous ankle arthroscopies for ankle impingement. The patient underwent arthroscopic removal of the OCL in combination with adipose-derived MSC therapy. The patient reported progressive improvement as measured by the validated Foot and Ankle Disability Index. Repeat MRI with additional T2 mapping techniques showed successful regeneration of hyaline-like cartilage. This case is the first to show the successful use of MSC therapy in the management of an ankle OCL. Trial registration: Australian New Zealand Clinical Trials Registry - ACTRN12617000638336.

Indexed as

AdultAnkle JointCartilage, ArticularHumansMaleMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteochondritis DissecansRegenerationTransplantation, AutologousTreatment Outcomeorthopaedicsosteoarthritissports and exercise medicine

Identifiers

PMID32641315
PMCPMC7348644
OpenAlexW3041600323

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.