ArticleVirology journal2020
Relapsing viral keratoconjunctivitis in COVID-19: a case report.
Article in Virology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Immune-Related Peripheral Keratopathy in Post-COVID-19 Syndrome.International medical case reports journal · 2025Article
- Review
- The Review of Ophthalmic Symptoms in COVID-19.Clinical ophthalmology (Auckland, N.Z.) · 2024Review
- Clinical spectrum of ocular manifestations in COVID-19: a case series.Infectious medicine · 2023Article
- SARS-CoV-2 infection and diabetes: Pathophysiological mechanism of multi-system organ failure.World journal of virology · 2022Review
- Recurrent keratoconjunctivitis as the sole manifestation of COVID-19 infection: A case report.European journal of ophthalmology · 2022Article
- How Does SARS-CoV-2 Affect Our Eyes-What Have We Learnt So Far about the Ophthalmic Manifestations of COVID-19?Journal of clinical medicine · 2022Review
- COVID-19 and the eye: alternative facts The 2022 Bowman Club, David L. Easty lecture.BMJ open ophthalmology · 2022Review
- Stromal interstitial keratitis in a patient with COVID-19.Journal francais d'ophtalmologie · 2022Article
- Ocular manifestations of recent viral pandemics: A literature review.Frontiers in medicine · 2022Review
- The effect of COVID-19 pandemic and wearing face masks on ophthalmology practice: What is known so far? A narrative review.Frontiers in medicine · 2022Review
- COVID-19: Update on Its Ocular Involvements, and Complications From Its Treatments and Vaccinations.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) · 2021Review
- Conjunctivitis as a sign of persistent SARS-COV-2 infection? An observational study and report of late symptoms.European journal of ophthalmology · 2021Article
- COVID-19 case presented initially with keratoconjunctivitis: A case report.Annals of medicine and surgery (2012) · 2021Article
- Transcriptomic analysis revealed increased expression of genes involved in keratinization in the tears of COVID-19 patients.Scientific reports · 2021Article
- Post-Mortem RT-PCR Assay for SARS-CoV-2 RNA in COVID-19 Patients' Corneal Epithelium, Conjunctival and Nasopharyngeal Swabs.Journal of clinical medicine · 2021Article
- SARS-CoV-2 and the Eyes: A Review of the Literature on Transmission, Detection, and Ocular Manifestations.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- Keep Eyes on COVID-19: Ophthalmic Symptoms and Potential Transmission of SARS-CoV-2 through the Oculus.Infectious diseases & immunity · 2021Review
- Ophthalmological Considerations for COVID-19 Vaccination in Patients with Inflammatory Eye Diseases and Autoimmune Disorders.Ophthalmology and therapy · 2021Article
- The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies.Cells · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, many studies have reported the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the conjunctival sac of patients infected with this virus, with several patients displaying symptoms of viral conjunctivitis. However, to our best knowledge, there is no in-depth report on the course of patients with COVID-19 complicated by relapsing viral conjunctivitis or keratoconjunctivitis. CASE PRESENTATION: A 53-year-old man confirmed with COVID-19 developed symptoms of viral conjunctivitis in the left eye approximately 10 days after the onset of COVID-19. The results of a nucleic acid test were positive for SARS-CoV-2 in the conjunctival sac of the left eye. The symptoms were relieved 6 days after treatment. However, the patient was subsequently diagnosed with viral keratoconjunctivitis in both eyes 5 days after the symptoms in the left eye were satisfactorily relieved. The disease progressed rapidly, with spot staining observed at the periphery of the corneal epithelium. Although SARS-CoV-2 could not be detected in conjunctival secretions, the levels of inflammatory factors, such as interleukin-6, were increased in both eyes. Both eyes were treated with glucocorticoids, and symptoms were controlled within 5 days. There was no recurrence.
conclusionsIn this case report, the pathogenesis, clinical manifestations, treatment, and outcome of a case with COVID-19 complicated by relapsing viral keratoconjunctivitis is described, and the involvement of topical cytokine surge in the pathogenesis of COVID-19 as it relates to viral keratoconjunctivitis is reported.
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