Observational studyCardiovascular diabetology2020
Impacts of triglyceride-glucose index on prognosis of patients with type 2 diabetes mellitus and non-ST-segment elevation acute coronary syndrome: results from an observational cohort study in China.
Observational study in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 12 of them syntheses that pooled it.
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Who cites it
125 citing papers in PubMed, 12 syntheses or guidelines pooled it.
- Triglyceride-glucose index as a novel predictor of major adverse cardiovascular events in patients with coronary revascularization: a meta-analysis of cohort studies.Annals of medicine · 2026Pooled it
- Does diabetes status modify the association between the triglyceride-glucose index and major adverse cardiovascular events in patients with coronary heart disease? A systematic review and meta-analysis of longitudinal cohort studies.Cardiovascular diabetology · 2025Pooled it
- Does diabetes modify the triglyceride-glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants.Cardiovascular diabetology · 2025Pooled it
- Diagnostic and prognostic value of triglyceride glucose index: a comprehensive evaluation of meta-analysis.Cardiovascular diabetology · 2024Pooled it
- The association of triglyceride-glucose index with major adverse cardiovascular and cerebrovascular events after acute myocardial infarction: a meta-analysis of cohort studies.Nutrition & diabetes · 2024Pooled it
- Triglyceride-glucose index's link to cardiovascular outcomes post-percutaneous coronary intervention in China: a meta-analysis.ESC heart failure · 2024Pooled it
- Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies.Cardiovascular diabetology · 2024Pooled it
- Triglyceride-glucose index and heart failure: a systematic review and meta-analysis.Cardiovascular diabetology · 2023Pooled it
- Triglyceride-glucose index and coronary artery disease: a systematic review and meta-analysis of risk, severity, and prognosis.Cardiovascular diabetology · 2023Pooled it
- Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis.Cardiovascular diabetology · 2022Pooled it
- Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis.Cardiovascular diabetology · 2022Pooled it
- Prognostic Significance of Triglyceride-Glucose Index for Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Association between the cumulative average triglyceride-glucose-waist circumference index and new-onset hypertension among Chinese middle-aged and older adults-a national prospective study.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Development and validation of a triglyceride-glucose index-based nomogram for predicting risk in STEMI patients undergoing primary PCI.BMC cardiovascular disorders · 2026Article
- Correlation between surrogate indicators of insulin resistance and all-cause mortality in patients with severe hemorrhagic stroke: a multicenter retrospective cohort study in the United States.Cardiovascular diabetology · 2026Article
- Association of the triglyceride-glucose index with one-year all-cause mortality in patients with spontaneous basal ganglia hemorrhage: a retrospective study.BMC neurology · 2026Article
- The Association Between Triglyceride-Glucose Index and Mortality Risk in Cardiovascular Disease Patients: A Meta-Analysis.Journal of clinical medicine research · 2026Article
- The combined predictive value of the triglyceride-glucose index and A Body Shape Index on all-cause mortality: a 26-year prospective cohort analysis from the Rancho Bernardo Study.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Integrated prognostic evaluation of TyG and TyG-BMI in critically ill patients with comorbid atrial fibrillation and ischemic stroke using machine learning.BMC neurology · 2026Article
- Albuminuria as a Key Factor Associated with Ambulatory Arterial Stiffness: A Hierarchical Multivariable Analysis.Journal of clinical medicine · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between triglyceride-glucose index (TyG index) and the prevalence and prognosis of cardiovascular disease has been confirmed by former studies. However, it remains uncertain whether TyG index has a prognostic impact in patients with type 2 diabetes mellitus (T2DM) and non-ST-segment elevation acute coronary syndrome (NSTE-ACS) undergoing percutaneous coronary intervention (PCI).
methodsThe study retrospectively enrolled 798 patients (mean age: 60.9 ± 8.3 years; 68.3% men) with T2DM and NSTE-ACS who underwent PCI at Beijing Anzhen Hospital from January to December 2015. TyG index was calculated as previously reported: ln [fasting TGs (mg/dL) * FBG (mg/dL)/2]. The primary endpoint was a composite of adverse events as follows: all-cause death, non-fatal myocardial infarction (MI) and ischemia-driven revascularization.
resultsTyG index was significantly higher in patients with a primary endpoint event compared with those without. Multivariate Cox proportional hazards analysis showed that 1-unit increase of TyG index was independently associated with higher risk of primary endpoint, independent of other risk factors [hazard ratio (HR) 3.208 per 1-unit increase, 95% confidence interval (CI) 2.400-4.289, P < 0.001]. The addition of TyG index to a baseline risk model had an incremental effect on the predictive value for adverse prognosis [AUC: baseline risk model, 0.800 vs. baseline risk model + TyG index, 0.856, P for comparison < 0.001; category-free net reclassification improvement (NRI) 0.346, P < 0.001; integrated discrimination improvement (IDI) 0.087, P < 0.001].
conclusionsIncreased TyG index is a significant predictor of adverse prognosis in patients with T2DM and NSTE-ACS undergoing PCI. Further studies need to be performed to determine whether interventions for TyG index have a positive impact on improving clinical prognosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.