ArticleRadiation oncology (London, England)2020
Online adaptive radiotherapy compared to plan selection for rectal cancer: quantifying the benefit.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Predicting VMAT patient-specific quality assurance outcome using a machine learning workflow.Physical and engineering sciences in medicine · 2026Article
- Development of CBCT-Guided Online Adaptive Radiotherapy.Cancers · 2026Review
- Benefits of daily online plan adaptation with reduced margins in neoadjuvant chemoradiotherapy for esophageal cancer.Physics and imaging in radiation oncology · 2026Article
- Setup and target volume shape variation in rectal cancer radiotherapy: a systematic literature review.Technical innovations & patient support in radiation oncology · 2026Review
- Determining optimal GTV-to-PGTV margins for CT-guided dose-escalated radiotherapy with daily image guidance in locally advanced rectal cancer.Journal of applied clinical medical physics · 2026Article
- Strategies to reduce intestinal toxicity in neoadjuvant management of locally advanced rectal cancer.Discover oncology · 2025Review
- A study of criteria-based online adaptive radiotherapy with radiomics and dosimetry for postoperative prostate cancer.Medical physics · 2025Article
- Qualitative and quantitative evaluation of the role of CBCT in rectal cancer radiotherapy.La Radiologia medica · 2025Review
- A feasibility study of deep learning prediction model for VMAT patient-specific QA.Frontiers in oncology · 2025Article
- Quality of density deformations in patient anatomy during synthetic CT guided online adaptive radiation therapy for pelvic cancer.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Article
- Evaluation of artificial intelligence-based autosegmentation for a high-performance cone-beam computed tomography imaging system in the pelvic region.Physics and imaging in radiation oncology · 2025Article
- Efficient strategy for magnetic resonance image-guided adaptive radiotherapy of rectal cancer using a library of reference plans.Physics and imaging in radiation oncology · 2025Article
- Estimation of adaptive radiation therapy requirements for rectal cancer: a two-center study.Radiation oncology (London, England) · 2024Article
- Online Adaptive Radiotherapy for an Elderly Patient With Locally Advanced Pancreatic Cancer.Cureus · 2024Article
- ROAR-A: re-optimization based Online Adaptive Radiotherapy of anal cancer, a prospective phase II trial protocol.BMC cancer · 2024Article
- Intrafraction Motion and Margin Assessment for Ethos Online Adaptive Radiotherapy Treatments of the Prostate and Seminal Vesicles.Advances in radiation oncology · 2024Article
- First implementation and results of online adaptive radiotherapy for cervical cancer based on CT-Linac combination.Frontiers in oncology · 2024Article
- Review of cone beam computed tomography based online adaptive radiotherapy: current trend and future direction.Radiation oncology (London, England) · 2023Review
- Integrating plan complexity and dosiomics features with deep learning in patient-specific quality assurance for volumetric modulated arc therapy.Radiation oncology (London, England) · 2023Article
- Advantages and robustness of partial VMAT with prone position for neoadjuvant rectal cancer evaluated by CBCT-based offline adaptive radiotherapy.Radiation oncology (London, England) · 2023Article
Corrections and comments
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Authors and funding
7 authors.
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Abstract
backgroundTo compare online adaptive radiation therapy (ART) to a clinically implemented plan selection strategy (PS) with respect to dose to the organs at risk (OAR) for rectal cancer.
methodsThe first 20 patients treated with PS between May-September 2016 were included. This resulted in 10 short (SCRT) and 10 long (LCRT) course radiotherapy treatment schedules with a total of 300 Conebeam CT scans (CBCT). New dual arc VMAT plans were generated using auto-planning for both the online ART and PS strategy. For each fraction bowel bag, bladder and mesorectum were delineated on daily Conebeam CTs. The dose distribution planned was used to calculate daily DVHs. Coverage of the CTV was calculated, as defined by the dose received by 99% of the CTV volume (D99%). The volume of normal tissue irradiated with 95% of the prescribed fraction dose was calculated by calculating the volume receiving 95% of the prescribed fraction or more dose minus the volume of the CTV. For each fraction the difference between the plan selection and online adaptive strategy of each DVH parameter was calculated, as well as the average difference per patient.
resultsTarget coverage remained the same for online ART. The median volume of the normal tissue irradiated with 95% of the prescribed dose dropped from 642 cm3 (PS) to 237 cm3 (online-ART)(p < 0.001). Online ART reduced dose to the OARs for all tested dose levels for SCRT and LCRT (p < 0.001). For V15Gy of the bowel bag the median difference over all fractions of all patients was - 126 cm
conclusionsOnline ART for rectal cancer reduces dose the OARs significantly compared to a clinically implemented plan selection strategy, without compromising target coverage.
trial registrationMedical Research Involving Human Subjects Act (WMO) does not apply to this study and was retrospectively approved by the Medical Ethics review Committee of the Academic Medical Center (W19_357 # 19.420; Amsterdam University Medical Centers, Location Academic Medical Center, Amsterdam, The Netherlands).
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