Evidence map›Paper›PMID 32640900›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2020

Low-Level Nanog Expression in the Regulation of Quiescent Endothelium.

Jugajyoti Baruah, Suhnrita Chaudhuri, Victoria Mastej, Cassondra Axen, Ryan Hitzman, Isabella M B Ribeiro, Kishore K Wary

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jugajyoti BaruahFrom the Department of Psychiatry, Harvard Medical School, Boston, MA (J.B.).
Suhnrita ChaudhuriDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Victoria MastejDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Cassondra AxenDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Ryan HitzmanDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Isabella M B RibeiroDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
Kishore K WaryDepartment of Pharmacology and Regenerative Medicine, University of Illinois, Chicago (V.M., S.C., C.A., R.H., I.M.B.R., K.K.W.).
University of Illinois Chicago · USHarvard University · US

Funding

TRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6M
Vascular Biology, Signaling and Therapeutics training programT32HL144459 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KITAJEWSKI, JAN K., WARY, KISHORE K · 2019 to 2023
$1.6M
NHLBI NIH HHS T32 HL007829NHLBI NIH HHS T32 HL144459
6 · The paper itself

Abstract

objectiveNanog is expressed in adult endothelial cells (ECs) at a low-level, however, its functional significance is not known. The goal of our study was to elucidate the role of Nanog in adult ECs using a genetically engineered mouse model system. Approach and Results: Biochemical analyses showed that Nanog is expressed in both adult human and mouse tissues. Primary ECs isolated from adult mice showed detectable levels of Nanog, Tert (telomerase reverse transcriptase), and eNos (endothelial nitric oxide synthase). Wnt3a (Wnt family member 3A) increased the expression of Nanog and hTERT (human telomerase reverse transcriptase) in ECs and increased telomerase activity in these cells. In a chromatin immunoprecipitation experiment, Nanog directly bound to the

conclusionsWe showed that low-level Nanog expression is required for normal EC homeostasis and angiogenesis in adulthood.

Indexed as

Cell ProliferationCellular SenescenceAnimalsApoptosisCells, CulturedCoronary VesselsEndothelial CellsEndothelium, VascularFemaleFibrosisHumansHuman Umbilical Vein Endothelial CellsMaleMice, Inbred C57BLMice, KnockoutNanog Homeobox ProteinNanog Homeobox ProteinNanog protein, mouseNitric Oxide Synthase Type IIINos3 protein, mouseTelomeraseTERT protein, humanTert protein, mouseWnt3A Proteincardiac hypertrophycoronary vesselsendothelial cellshaploinsufficiencyquiescencetamoxifentelomerase

Identifiers

PMID32640900
PMCPMC7447188
OpenAlexW3041771829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.