Evidence map›Paper›PMID 32640833›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2020

Fas ligand neutralization attenuates hypertension, endothelin-1, and placental inflammation in an animal model of HELLP syndrome.

Jacob Gibbens, Shauna-Kay Spencer, Lucia Solis, Teylor Bowles, Patrick B Kyle, Jamie L Szczepanski, John Polk Dumas, Reanna Robinson, Kedra Wallace

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jacob GibbensDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Shauna-Kay SpencerDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Lucia SolisDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Teylor BowlesDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Patrick B KyleDepartment of Pathology, University of Mississippi Medical Center, Jackson, Mississippi.
Jamie L SzczepanskiDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
John Polk DumasDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Reanna RobinsonDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
Kedra WallaceDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, Mississippi.
University of Mississippi Medical Center · USJackson Memorial Hospital · US

Funding

Role of obesity in preeclamptic pregnancy.P20GM121334 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI Pier Paolo Claudio, Babbette LaMarca · 2017 to 2026
$26.4M
NIGMS NIH HHS P20 GM121334
6 · The paper itself

Abstract

Neutralization of FasL is linked to suppression of hypertension, placental inflammation, and endothelin system activation in an animal model of hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. During HELLP syndrome the placenta has been reported to serve as the primary source of Fas ligand (FasL), which has an impact on inflammation and hypertension during pregnancy and is dysregulated in women with severe preeclampsia and HELLP syndrome. We hypothesize that neutralization of FasL during pregnancy in an animal model of HELLP syndrome decreases inflammation and placental apoptosis, improves endothelial damage, and improves hypertension. On gestational

Indexed as

AnimalsAntibodies, NeutralizingDisease Models, AnimalEndothelin-1Fas Ligand ProteinFemaleHELLP SyndromeImmunoglobulin GPlacentaPregnancyRatsRats, Sprague-DawleyTreatment OutcomeTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Receptor-1Antibodies, NeutralizingEndothelin-1Fas Ligand ProteinImmunoglobulin GTumor Necrosis Factor-alphaVascular Endothelial Growth Factor Receptor-1FasHELLP syndromehypertensionpreeclampsiaTNF

Identifiers

PMID32640833
PMCPMC7473892
OpenAlexW3040845413

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.