Evidence map›Paper›PMID 32640635›Full record

ArticleMaterials (Basel, Switzerland)2020

Assessment and Characterization of Some New Photosensitizers for Antimicrobial Photodynamic Therapy (aPDT).

Laura Monica Dascalu Rusu, Marioara Moldovan, Doina Prodan, Irina Ciotlaus, Violeta Popescu, Ioana Baldea, Rahela Carpa, Sorina Sava, Radu Chifor, Mindra Eugenia Badea

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  4. Divulging the potency of naturally derived photosensitizers in green PDT: an inclusive review Of mechanisms, advantages, and future prospects.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Laura Monica Dascalu RusuDepartment of Prosthodontics and Dental Materials, Iuliu Hatieganu University of Medicine and Pharmacy, 31 Avram Iancu Str, 400083 Cluj-Napoca, Romania.
Marioara MoldovanInstitute of Chemistry Raluca Ripan, Babes-Bolyai University, 30 Fantanele Str, 400294 Cluj-Napoca, Romania.
Doina ProdanInstitute of Chemistry Raluca Ripan, Babes-Bolyai University, 30 Fantanele Str, 400294 Cluj-Napoca, Romania.
Irina CiotlausInstitute of Chemistry Raluca Ripan, Babes-Bolyai University, 30 Fantanele Str, 400294 Cluj-Napoca, Romania.
Violeta PopescuPhysics and Chemistry Department, Technical University of Cluj-Napoca, 28 Memorandumului Str, 400114 Cluj-Napoca, Romania.
Ioana BaldeaDepartment of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400083 Cluj-Napoca, Romania.
Rahela CarpaDepartment of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babeș Bolyai University, 1 M. Kogălniceanu Str, 400084 Cluj-Napoca, Romania.ORCID 0000-0001-8974-1718
Sorina SavaDepartment of Prosthodontics and Dental Materials, Iuliu Hatieganu University of Medicine and Pharmacy, 31 Avram Iancu Str, 400083 Cluj-Napoca, Romania.
Radu ChiforDepartment of Preventive Dental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 31 Avram Iancu Str, 400083 Cluj-Napoca, Romania.
Mindra Eugenia BadeaDepartment of Preventive Dental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 31 Avram Iancu Str, 400083 Cluj-Napoca, Romania.
Iuliu Hațieganu University of Medicine and Pharmacy · ROBabeș-Bolyai University · ROTechnical University of Cluj-Napoca · RO

Funding

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PNIII-P2-2.1-PED-2016-1415, no. 142-PED/2017
6 · The paper itself

Abstract

The novelty of this study consists on the formulation and evaluation of five complex experimental natural photosensitizers (PS): gel with oregano essential oil (O), gel with methylene blue (AM), gel with a mixture of essential oils (Thieves-H), gel with arnica oil and curcuma extract (CU) and gel with frankincense essential oil (T), used as photosensitizing agents (PS) in antimicrobial photodynamic therapy (aPDT) in the control of microbial biofilm in oral cavity. The experimental PS were characterized by gas chromatography-mass spectrometry (GC-MS), Fourier-transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, cytotoxicity assay, antimicrobial effect and scanning electron microscopy (SEM). The IR spectra of the experimental PS with essential oils exhibit absorption bands due to the presence of water and glycerol in high quantities. The studied compounds had a reduced cytotoxic effect on cell cultures. The lowest cytotoxic effect was observed in experimental PS with oregano essential oil and methylene blue PS. Essential oils with proven antibacterial capabilities used in experimental PS confer antibacterial activity to the gels in which they are incorporated, an activity that may be more efficient use of a PDT therapy. Single bacteria were detected mainly by SEM after 12 h, while aggregate bacteria and micro colonies dominated the samples at 48 h.

Indexed as

antimicrobial photodynamic therapybiofilmsgelsphotosensitizers

Identifiers

PMID32640635
PMCPMC7372345
OpenAlexW3038980111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.