Evidence map›Paper›PMID 32640629›Full record

ArticleViruses2020

Phylogenetic and Timescale Analysis of Barmah Forest Virus as Inferred from Genome Sequence Analysis.

Alice Michie, Timo Ernst, I-Ly Joanna Chua, Michael D A Lindsay, Peter J Neville, Jay Nicholson, Andrew Jardine, John S Mackenzie, David W Smith, Allison Imrie

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Alice MichieSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia.
Timo ErnstSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia.
I-Ly Joanna ChuaPathWest Laboratory Medicine Western Australia, Perth, WA 6000, Australia.
Michael D A LindsayEnvironmental Health Hazards, Department of Health, Perth, WA 6000, Australia.
Peter J NevilleEnvironmental Health Hazards, Department of Health, Perth, WA 6000, Australia.
Jay NicholsonEnvironmental Health Hazards, Department of Health, Perth, WA 6000, Australia.
Andrew JardineEnvironmental Health Hazards, Department of Health, Perth, WA 6000, Australia.
John S MackenziePathWest Laboratory Medicine Western Australia, Perth, WA 6000, Australia.ORCID 0000-0002-5918-2190
David W SmithPathWest Laboratory Medicine Western Australia, Perth, WA 6000, Australia.ORCID 0000-0002-3107-5182
Allison ImrieSchool of Biomedical Sciences, University of Western Australia, Nedlands, WA 6009, Australia.ORCID 0000-0003-4715-6662
Government of Western Australia Department of Health · AUThe University of Western Australia · AUPathwest Laboratory Medicine · AUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Barmah Forest virus (BFV) is a medically important mosquito-borne alphavirus endemic to Australia. Symptomatic disease can be a major cause of morbidity, associated with fever, rash, and debilitating arthralgia. BFV disease is similar to that caused by Ross River virus (RRV), the other major Australian alphavirus. Currently, just four BFV whole-genome sequences are available with no genome-scale phylogeny in existence to robustly characterise genetic diversity. Thirty novel genome sequences were derived for this study, for a final 34-taxon dataset sampled over a 44 year period. Three distinct BFV genotypes were characterised (G1-3) that have circulated in Australia and Papua New Guinea (PNG). Evidence of spatio-temporal co-circulation of G2 and G3 within regions of Australia was noted, including in the South West region of Western Australia (WA) during the first reported disease outbreaks in the state's history. Compared with RRV, the BFV population appeared more stable with less frequent emergence of novel lineages. Preliminary in vitro assessment of RRV and BFV replication kinetics found that RRV replicates at a significantly faster rate and to a higher, more persistent titre compared with BFV, perhaps indicating mosquitoes may be infectious with RRV for longer than with BFV. This investigation resolved a greater diversity of BFV, and a greater understanding of the evolutionary dynamics and history was attained.

Indexed as

Genome, ViralPhylogenyWhole Genome SequencingAlphavirusAlphavirus InfectionsAnimalsAustraliaChlorocebus aethiopsCulicidaeGenetic VariationPapua New GuineaSequence Analysis, DNATime FactorsVero CellsVirus ReplicationalphavirusarbovirusAustraliaevolutionary analysisphylogeny

Identifiers

PMID32640629
PMCPMC7412159
OpenAlexW3040618373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.