Evidence map›Paper›PMID 32640609›Full record

ArticleViruses2020

In Silico Prediction of Human Leukocytes Antigen (HLA) Class II Binding Hepatitis B Virus (HBV) Peptides in Botswana.

Wonderful Tatenda Choga, Motswedi Anderson, Edward Zumbika, Bonolo B Phinius, Tshepiso Mbangiwa, Lynnette N Bhebhe, Kabo Baruti, Peter Opiyo Kimathi, Kaelo K Seatla, Rosemary M Musonda and 4 more

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Peptides for Vaccine Development.ACS applied bio materials · 2022
    Review
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 4 countries.

Wonderful Tatenda ChogaResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.ORCID 0000-0001-7606-0569
Motswedi AndersonResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.ORCID 0000-0001-9974-9684
Edward ZumbikaDepartment of Applied Biology and Biochemistry, Faculty of Applied Sciences, National University of Science and Technology, Bulawayo 0000, Zimbabwe.
Bonolo B PhiniusResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Tshepiso MbangiwaResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Lynnette N BhebheResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Kabo BarutiResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Peter Opiyo KimathiCentre for Proteomic and Genomic Research, Cape Town 7925, South Africa.
Kaelo K SeatlaResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.ORCID 0000-0002-2190-2842
Rosemary M MusondaResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Trevor Graham BellP.O. Box 497, Wits, Johannesburg 2050, South Africa.ORCID 0000-0003-2630-7513
Sikhulile MoyoResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.ORCID 0000-0003-3821-4592
Jason T BlackardDivision of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.ORCID 0000-0003-2876-3811
Simani GaseitsiweResearch Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Botswana Harvard AIDS Institute Partnership · BWHarvard University · USUniversity of Botswana · BWUniversity of Cape Town · ZAAfrican Organisation for Research and Training in Cancer · ZANational University of Science and Technology · ZWResearch ICT Africa · ZAUniversity of Cincinnati Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) is the primary cause of liver-related malignancies worldwide, and there is no effective cure for chronic HBV infection (CHB) currently. Strong immunological responses induced by T cells are associated with HBV clearance during acute infection; however, the repertoire of epitopes (

Indexed as

AllelesBotswanaComputer SimulationEpitopes, T-LymphocyteGenes, MHC Class IIHepatitis BHepatitis B Surface AntigensHepatitis B virusHLA AntigensHumansLeukocytesT-LymphocytesEpitopes, T-LymphocyteHepatitis B Surface AntigensHLA AntigensAfricaBotswanacandidate multi-epitope vaccines (MEV)escape mutationhepatitis B virus (HBV)HLA class II allelesimmunoinformaticsin silicoT-cell epitopes

Identifiers

PMID32640609
PMCPMC7412261
OpenAlexW3038924028

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.