Evidence map›Paper›PMID 32640605›Full record

ReviewCells2020

Kinase-Independent Functions of MASTL in Cancer: A New Perspective on MASTL Targeting.

James Ronald William Conway, Elisa Närvä, Maria Emilia Taskinen, Johanna Ivaska

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

James Ronald William ConwayTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Elisa NärväTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Maria Emilia TaskinenTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Johanna IvaskaTurku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.
Åbo Akademi University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microtubule-associated serine/threonine kinase-like (MASTL; Greatwall) is a well-characterized kinase, whose catalytic role has been extensively studied in relation to cell-cycle acceleration. Importantly, MASTL has been implicated to play a substantial role in cancer progression and subsequent studies have shown that MASTL is a significant regulator of the cellular actomyosin cytoskeleton. Several kinases have non-catalytic properties, which are essential or even sufficient for their functions. Likewise, MASTL functions have been attributed both to kinase-dependent phosphorylation of downstream substrates, but also to kinase-independent regulation of the actomyosin contractile machinery. In this review, we aimed to highlight the catalytic and non-catalytic roles of MASTL in proliferation, migration, and invasion. Further, we discussed the implications of this dual role for therapeutic design.

Indexed as

ActinsAnimalsCell CycleCell ProliferationHumansMicrotubule-Associated ProteinsNeoplasmsPhosphorylationProtein Serine-Threonine KinasesActinsMASTL protein, humanMicrotubule-Associated ProteinsProtein Serine-Threonine Kinasesactincancercell cyclecontractilitykinase inhibitorMASTLtherapeutic targeting

Identifiers

PMID32640605
PMCPMC7407770
OpenAlexW3039342879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.