ReviewCells2020
A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?
Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 193 citations in OpenAlex.
- Clinical application of traditional Chinese medicine powder in the treatment of acute and chronic wounds.International wound journal · 2023Trial
- A Narrative Review of Advances in Skin Tissue Engineering: From Physiological Architecture to 3D Bioprinting.Cureus · 2026Review
- Role of polymeric nanocomposite for tissue engineering applications.RSC advances · 2026Review
- Optical, Tomographic, and Mass Spectrometry Imaging Methods for Burn Wounds: Capabilities, Limitations, and Clinical Potential.Biomedicines · 2026Review
- RNA Coding and Transcriptional Regulation in Skin Repair: Insights from Single-Cell Profiling and Implications for Organoid-Based Regenerative Strategies.Life (Basel, Switzerland) · 2026Review
- Photoactive Hydrogels Containing Merocyanine/Spiropyran Units for Wound Dressing Applications.Biomacromolecules · 2026Article
- Modification of Natural Clays with Magnetite to Provide Boosted Antimicrobial Properties and Chemopreventive Activity Against Melanoma.Materials (Basel, Switzerland) · 2025Article
- Hydrogel-Based Nitric Oxide Delivery Systems for Enhanced Wound Healing.Gels (Basel, Switzerland) · 2025Review
- Greener Decellularization of Porcine Auricular Cartilage Using Supercritical Technology and Different Pretreatments for Application in Tissue Engineering.ACS biomaterials science & engineering · 2025Article
- Tri-Layered Full-Thickness Artificial Skin Incorporating Adipose-Derived Stromal Vascular Fraction Cells, Keratinocytes, and a Basement Membrane.Bioengineering (Basel, Switzerland) · 2025Article
- Construction of a deep learning-based predictive model to evaluate the influence of mechanical stretching stimuli on MMP-2 gene expression levels in fibroblasts.Biomedical engineering online · 2025Article
- Multifunctional tri-layer wound dressing containing ZNO nanoparticles and IGF-1 as an efficient biomaterial for healing of full thickness skin injuries.Asian journal of pharmaceutical sciences · 2025Article
- Review on Current Advancements in Facilitation of Burn Wound Healing.Bioengineering (Basel, Switzerland) · 2025Review
- Cellulose-Based Nanofibers Infused with Biotherapeutics for Enhanced Wound-Healing Applications.ACS polymers Au · 2025Review
- Effects of the combination of platelet-rich plasma and stromal vascular fraction on the level of platelet-derived growth factor-bb in the wound remodeling of full-thickness burn injuries in wistar rats.Annals of burns and fire disasters · 2025Article
- Molecular Diffusion and Optical Properties of Implantable Collagen Materials.Materials (Basel, Switzerland) · 2025Article
- A hybrid scaffold of modified human amniotic membrane with gelatine/dendrimer-protected silver nanoparticles for skin wound healing applications.RSC advances · 2025Article
- Evaluation of the antibacterial properties of four bioactive biomaterials for chronic wound management.Future microbiology · 2025Article
- The effect of broccoli stem extract cream (Frontiers in medicine · 2025Article
- Rab7 inhibitor enhances stem cell differentiation into keratinocyte-like cells with anti-inflammatory properties.Frontiers in immunology · 2025Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds occur as a consequence of a prolonged inflammatory phase during the healing process, which precludes skin regeneration. Typical treatment for chronic wounds includes application of autografts, allografts collected from cadaver, and topical delivery of antioxidant, anti-inflammatory, and antibacterial agents. Nevertheless, the mentioned therapies are not sufficient for extensive or deep wounds. Moreover, application of allogeneic skin grafts carries high risk of rejection and treatment failure. Advanced therapies for chronic wounds involve application of bioengineered artificial skin substitutes to overcome graft rejection as well as topical delivery of mesenchymal stem cells to reduce inflammation and accelerate the healing process. This review focuses on the concept of skin tissue engineering, which is a modern approach to chronic wound treatment. The aim of the article is to summarize common therapies for chronic wounds and recent achievements in the development of bioengineered artificial skin constructs, including analysis of biomaterials and cells widely used for skin graft production. This review also presents attempts to reconstruct nerves, pigmentation, and skin appendages (hair follicles, sweat glands) using artificial skin grafts as well as recent trends in the engineering of biomaterials, aiming to produce nanocomposite skin substitutes (nanofilled polymer composites) with controlled antibacterial activity. Finally, the article describes the composition, advantages, and limitations of both newly developed and commercially available bioengineered skin substitutes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.