Evidence map›Paper›PMID 32640548›Full record

ArticleInternational journal of molecular sciences2020

Tumors Resistant to Checkpoint Inhibitors Can Become Sensitive after Treatment with Vascular Disrupting Agents.

Michael R Horsman, Thomas R Wittenborn, Patricia S Nielsen, Pernille B Elming

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michael R HorsmanExperimental Clinical Oncology-Department of Oncology, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Thomas R WittenbornExperimental Clinical Oncology-Department of Oncology, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Patricia S NielsenDepartment of Pathology, Aarhus University Hospital, DK-8200 Aarhus, Denmark.ORCID 0000-0002-7859-6321
Pernille B ElmingExperimental Clinical Oncology-Department of Oncology, Aarhus University Hospital, DK-8200 Aarhus, Denmark.
Aarhus University Hospital · DK

Funding

Danish Council for Independent Research: Medical Sciences DFF - 4004-00362Kræftens Bekæmpelse R40-A2022-11-S2
6 · The paper itself

Abstract

Immune therapy improves cancer outcomes, yet many patients do not respond. This pre-clinical study investigated whether vascular disrupting agents (VDAs) could convert an immune unresponsive tumor into a responder. CDF1 mice, with 200 mm

Indexed as

AnimalsAntineoplastic Agents, PhytogenicAntineoplastic Combined Chemotherapy ProtocolsB7-H1 AntigenBibenzylsCTLA-4 AntigenDiphosphatesDisease ProgressionDrug Resistance, NeoplasmFemaleImmune Checkpoint InhibitorsMaleMammary Neoplasms, AnimalMiceMice, Inbred C3HNeovascularization, PathologicAntineoplastic Agents, PhytogenicB7-H1 AntigenBibenzylsCD274 protein, humancombretastatinCTLA-4 AntigenCTLA4 protein, humanDiphosphatesImmune Checkpoint InhibitorsOxi 4503Stilbenesanti-CTLA-4anti-PD-1anti-PD-L1C3H mammary carcinomacheckpoint inhibitorscombretastatinOXi43503tumor growth delayvascular disrupting agents

Identifiers

PMID32640548
PMCPMC7370297
OpenAlexW3038299509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.