Evidence map›Paper›PMID 32640257›Full record

ArticleImmunity2020

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8

Henrique Borges da Silva, Changwei Peng, Haiguang Wang, Kelsey M Wanhainen, Chaoyu Ma, Sharon Lopez, Alexander Khoruts, Nu Zhang, Stephen C Jameson

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed, 1 pooled it
9.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. KLF2 overrides the resident memory CD8 T cell differentiation program, in opposition to KLF3.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Glomerular endothelial cells eliminate nicotinamide adenine dinucleotide to instruct CD103Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Tissue-resident memory CD8Nature reviews. Gastroenterology & hepatology · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. CCR2Cellular & molecular immunology · 2025
    Article
  19. Review
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Henrique Borges da SilvaCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Changwei PengCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Haiguang WangCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Kelsey M WanhainenCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.
Chaoyu MaDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Sharon LopezDepartment of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Alexander KhorutsDepartment of Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
Nu ZhangDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.
Stephen C JamesonCenter for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: james024@umn.edu.
University of Minnesota · USThe University of Texas Health Science Center at San Antonio · US

Funding

T Cell HomeostasisR01AI038903 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI STEPHEN C JAMESON · 2001 to 2026
$5.9M
Regulation of T cell responses by P2RX7R01AI145147 · NIAID · UNIVERSITY OF MINNESOTA · PI JAMESON, STEPHEN C · 2019 to 2023
$3.3M
Control of antiviral memory CD8+ T cell longevity by extracellular ATP sensingR01AI170649 · NIAID · MAYO CLINIC ARIZONA · PI Henrique Borges da Silva · 2022 to 2026
$2.4M
DEFINING THE FUNCTION OF EXTRACELLULAR ATP SENSING FOR MEMORY CD8+ T CELL GENERATION AND LONGEVITYR00AI139381 · NIAID · MAYO CLINIC ARIZONA · PI BORGES DA SILVA, HENRIQUE · 2020 to 2021
$498k
Defining the function of extracellular ATP sensing for memory CD8+ T cell generation and longevityK99AI139381 · NIAID · UNIVERSITY OF MINNESOTA · PI BORGES DA SILVA, HENRIQUE · 2019 to 2019
$100k
NIAID NIH HHS K99 AI139381NIAID NIH HHS R00 AI139381NIAID NIH HHS R01 AI038903NIAID NIH HHS R01 AI145147NIAID NIH HHS R01 AI170649
6 · The paper itself

Abstract

Tissue-resident memory (Trm) CD8

Indexed as

Adenosine TriphosphateAnimalsCalcineurinCD8-Positive T-LymphocytesImmunologic MemoryMiceMice, Inbred C57BLMice, TransgenicReceptors, Purinergic P2X7Receptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betaAdenosine TriphosphateCalcineurinP2rx7 protein, mouseReceptors, Purinergic P2X7Receptor, Transforming Growth Factor-beta Type IITgfbr2 protein, mouseTransforming Growth Factor betaeATPmemory CD8(+) T cellsnon-lymphoid tissueP2RX7TGF-β

Identifiers

PMID32640257
PMCPMC8026201
OpenAlexW3038145449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.