ArticleCell reports2020
Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 94 citations in OpenAlex.
- Reward-tethered place cells support flexible magnitude coding and remapping in the hippocampus.bioRxiv : the preprint server for biology · 2026Article
- The dentate gyrus efficiently converges LEC and MEC inputs into multimodal, highly specific and reliable environmental representations.Nature neuroscience · 2026Article
- A scalable hippocampal code for flexible interval timing through persistent activity.bioRxiv : the preprint server for biology · 2026Article
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- Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.Journal of neurochemistry · 2026Review
- Hierarchical Distribution of Reward Representation in the Cortical and Hippocampal Regions.eNeuro · 2026Article
- Unconstrained Plasticity Disrupts Memory Consolidation in a Mouse Model of Rett Syndrome.bioRxiv : the preprint server for biology · 2026Article
- Environmental enrichment accelerates the stabilization of cortical representation duringiScience · 2026Article
- Explicit error coding can mediate gain recalibration in continuous bump attractor networks.Nature communications · 2025Article
- Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment.iScience · 2025Article
- Environmental enrichment accelerates cortical memory consolidation.bioRxiv : the preprint server for biology · 2025Article
- Formation of an expanding memory representation in the hippocampus.Nature neuroscience · 2025Article
- A flexible hippocampal population code for experience relative to reward.Nature neuroscience · 2025Article
- Diminished Social Memory and Hippocampal Correlates of Social Interactions in Chronic Social Defeat Stress Susceptibility.Biological psychiatry global open science · 2025Article
- Parallel processing of past and future memories through reactivation and synaptic plasticity mechanisms during sleep.Nature communications · 2025Article
- Impaired spatial coding of the hippocampus in a dentate gyrus hypoplasia mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Navigating uncertainty: reward location variability induces reorganization of hippocampal spatial representations.bioRxiv : the preprint server for biology · 2025Article
- Hierarchical Gradients of Encoded Spatial and Sensory Information in the Neocortex Are Attenuated by Dorsal Hippocampal Lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Multiphoton imaging of hippocampal neural circuits: techniques and biological insights into region-, cell-type-, and pathway-specific functions.Neurophotonics · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 8 institutions in 4 countries.
Funding
Abstract
In the hippocampus, locations associated with salient features are represented by a disproportionately large number of neurons, but the cellular and molecular mechanisms underlying this over-representation remain elusive. Using longitudinal calcium imaging in mice learning to navigate in virtual reality, we find that the over-representation of reward and landmark locations are mediated by persistent and separable subsets of neurons, with distinct time courses of emergence and differing underlying molecular mechanisms. Strikingly, we find that in mice lacking Shank2, an autism spectrum disorder (ASD)-linked gene encoding an excitatory postsynaptic scaffold protein, the learning-induced over-representation of landmarks was absent whereas the over-representation of rewards was substantially increased, as was goal-directed behavior. These findings demonstrate that multiple hippocampal coding processes for unique types of salient features are distinguished by a Shank2-dependent mechanism and suggest that abnormally distorted hippocampal salience mapping may underlie cognitive and behavioral abnormalities in a subset of ASDs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.