Evidence map›Paper›PMID 32640222›Full record

ArticleCell reports2020

Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.

Emilia H Moscato, Christine Dubowy, James A Walker, Matthew S Kayser

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Neurofibromin Deficiency Alters the Patterning and Prioritization of Motor Behaviors in a State-Dependent Manner.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Modeling neurodegenerative and neurodevelopmental disorders in theLearning & memory (Cold Spring Harbor, N.Y.) · 2024
    Review
  8. Cells · 2024
    Review
  9. Article
  10. Article
  11. Loss ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  12. Article
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Emilia H MoscatoDepartment of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.
Christine DubowyDepartment of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA.
James A WalkerCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
Matthew S KayserDepartment of Psychiatry, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Neuroscience, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA; Chronobiology and Sleep Institute, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: kayser@pennmedicine.upenn.edu.
University of Pennsylvania · USMassachusetts General Hospital · US

Funding

The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ABEL, EDWIN TED G. · 2016 to 2020
$6.3M
Building brains in our sleep: A Drosophila larval platform for examining sleep and neurogenesisDP2NS111996 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAYSER, MATTHEW S · 2018 to 2018
$2.4M
Functional analysis of pathogenic mutations in Neurofibromatosis Type-1 (NF1)R21NS096402 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WALKER, JAMES ANTHONY · 2016 to 2017
$465k
NICHD NIH HHS U54 HD086984NINDS NIH HHS DP2 NS111996NINDS NIH HHS R21 NS096402
6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) is a neurodevelopmental disorder associated with social and communicative disabilities. The cellular and circuit mechanisms by which loss of neurofibromin 1 (Nf1) results in social deficits are unknown. Here, we identify social behavioral dysregulation with Nf1 loss in Drosophila. These deficits map to primary dysfunction of a group of peripheral sensory neurons. Nf1 regulation of Ras signaling in adult ppk23

Indexed as

Social BehaviorAgingAnimalsBehavior, AnimalCourtshipDrosophila melanogasterDrosophila ProteinsFemaleMaleMutationNerve Tissue Proteinsras GTPase-Activating Proteinsras ProteinsSensory Receptor CellsSignal TransductionDrosophila ProteinsNerve Tissue ProteinsNF1 protein, Drosophilaras GTPase-Activating Proteinsras ProteinsautismDrosophila melanogastergustatory sensory neuronsneural circuitsneurofibromatosis type 1neurofibromin 1ppk23Rassensory processingsocial behavior

Identifiers

PMID32640222
PMCPMC7416787
OpenAlexW3040187523

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.