Evidence map›Paper›PMID 32640083›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2021

Bidirectional links between adolescent brain function and substance use moderated by cognitive control.

Jungmeen Kim-Spoon, Toria Herd, Alexis Brieant, Kristin M Peviani, Nina Lauharatanahirun, Jacob Lee, Kirby Deater-Deckard, Warren K Bickel, Brooks King-Casas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Alcohol and Cannabis Use and the Developing Brain.Alcohol research : current reviews · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Jungmeen Kim-SpoonDepartment of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Toria HerdDepartment of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Alexis BrieantDepartment of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Kristin M PevianiDepartment of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Nina LauharatanahirunU.S. Army Research Laboratory, Aberdeen Proving Ground, Aberdeen, MD, USA.
Jacob LeeFralin Biomedical Research Institute at VTC, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Kirby Deater-DeckardDepartment of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst, MA, USA.ORCID 0000-0003-4151-2152
Warren K BickelDepartment of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Brooks King-CasasDepartment of Psychology, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
Virginia Tech · USBiomedical Research Institute · USDEVCOM Army Research Laboratory · USUniversity of Massachusetts Amherst · US

Funding

Neurobehavioral Determinants of Health Risk Behaviors: From Adolescence to Young AdulthoodR01DA036017 · NIDA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CASAS, BROOKS, KIM-SPOON, JUNGMEEN · 2013 to 2022
$7.2M
Neurobehavioral mechanisms of substance use and protective behaviors in adolescentsF31DA042594 · NIDA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI LAUHARATANAHIRUN, NINA · 2016 to 2017
$42k
NIDA NIH HHS F31 DA042594NIDA NIH HHS R01 DA036017
6 · The paper itself

Abstract

backgroundNo clear consensus exists as to whether neurodevelopmental abnormalities among substance users reflect predisposing neural risk factors, neurotoxic effects of substances, or both. Using a longitudinal design, we examined developmental patterns of the bidirectional links between neural mechanisms and substance use throughout adolescence.

method167 adolescents (aged 13-14 years at Time 1, 53% male) were assessed annually four times. Risk-related neural processing was assessed by blood-oxygen-level-dependent responses in the insula during a lottery choice task, cognitive control by behavioral performance during the Multi-Source Interference Task, and substance use by adolescents' self-reported cigarette, alcohol, and marijuana use.

resultsLatent change score modeling indicated that greater substance use predicted increased insula activation during risk processing, but the effects of insula activation on changes in substance use were not significant. The coupling effect from substance use to insula activation was particularly strong for adolescents with low cognitive control, which supports the theorized moderating role of cognitive control.

conclusionsOur results elucidate how substance use may alter brain development to be biased toward maladaptive decision-making, particularly among adolescents with poor cognitive control. Furthermore, the current findings underscore that cognitive control may be an important target in the prevention and treatment of adolescent substance use given its moderating role in the neuroadaptive effects of substance use on brain development.

Indexed as

Risk-TakingSubstance-Related DisordersAdolescentBrainCerebral CortexCognitionFemaleHumansMagnetic Resonance ImagingMalecognitive controlfunctional neuroimaginginsula activationNeural risk processingneurotoxic effectssubstance use

Identifiers

PMID32640083
PMCPMC8124751
OpenAlexW3041780270

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.