ArticleJournal of neurophysiology2020
Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects.
Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of age and noise exposure history on auditory nerve response amplitudes: A systematic review, study, and meta-analysis.Hearing research · 2024Pooled it
- Article
- Comparing physiological signatures of synaptopathic noise exposure and carboplatin-induced inner-hair-cell dysfunction in chinchillas.Hearing research · 2026Article
- Targeting Sensory Neuropathies Through Neurotrophin-Based Approaches.Cellular and molecular neurobiology · 2026Review
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model.bioRxiv : the preprint server for biology · 2026Article
- Neural Hearing Loss: Mechanisms, Diagnosis and Treatment Horizons.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- The Search for a Diagnostic Indicator of Cochlear Deafferentation: Predicting Age and Veteran Status from Auditory Evoked Potential Measures.medRxiv : the preprint server for health sciences · 2025Article
- Consequences and Mechanisms of Noise-Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Arousal state fluctuations are a source of internal noise underlying age-related declines in speech intelligibility.bioRxiv : the preprint server for biology · 2025Article
- Article
- A Systematic Review: State of the Science on Diagnostics of Hidden Hearing Loss.Diagnostics (Basel, Switzerland) · 2025Review
- Cochlear Synaptopathy Evaluation With Electrocochleography in Patients With Hearing Difficulty in Noise Despite Normal Hearing Levels.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
- I' Wave Auditory Brainstem Response as a Possible Indicator of Noise-Induced Cochlear Synaptopathy.Iranian journal of child neurology · 2025Article
- Modeling the impact of cochlear nerve degeneration on speech recognition performance.PloS one · 2025Article
- The effect of speech masking on the human subcortical response to continuous speech.bioRxiv : the preprint server for biology · 2024Article
- Changing Knowledge, Principles, and Technology in Contemporary Clinical Audiological Practice: A Narrative Review.Journal of clinical medicine · 2024Review
- Aging effects on the neural representation and perception of consonant transition cues.Hearing research · 2024Article
- Predictors of Speech-in-Noise Understanding in a Population of Occupationally Noise-Exposed Individuals.Biology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Hearing loss caused by noise exposure, ototoxic drugs, or aging results from the loss of sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss of hair cells can be preceded by loss of auditory-nerve peripheral synapses, which likely degrades auditory processing. While this condition, known as cochlear synaptopathy, can be diagnosed in mice by a reduction of suprathreshold cochlear neural responses, its diagnosis in humans remains challenging. To look for evidence of cochlear nerve damage in normal hearing subjects, we measured their word recognition performance in difficult listening environments and compared it to cochlear function as assessed by otoacoustic emissions and click-evoked electrocochleography. Several electrocochleographic markers were correlated with word scores, whereas distortion product otoacoustic emissions were not. Specifically, the summating potential (SP) was larger and the cochlear nerve action potential (AP) was smaller in those with the worst word scores. Adding a forward masker or increasing stimulus rate reduced SP in the worst performers, suggesting that this potential includes postsynaptic components as well as hair cell receptor potentials. Results suggests that some of the variance in word scores among listeners with normal audiometric threshold arises from cochlear neural damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.