Evidence map›Paper›PMID 32639618›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2020

N-Aryl Amides as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents.

Xuekang Cai, Jia Zhang, Jiaqi Lu, Long Yi, Zheng Han, Shuixing Zhang, Xing Yang, Guanshu Liu

Open access · greenAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Xuekang CaiDepartment of Nuclear Medicine, Peking University First Hospital, 100034, Beijing, P. R. China.
Jia ZhangRussell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.
Jiaqi LuDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, 21218, USA.
Long YiState Key Laboratory of Organic-Inorganic Composites and Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology, 15 Beisanhuan East Road, Chaoyang District, 100029, Beijing, P. R. China.
Zheng HanRussell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.
Shuixing ZhangDepartment of Radiology, The First Affiliated Hospital of Jinan University, 510632, Guangzhou, Guandong, P. R. China.
Xing YangDepartment of Nuclear Medicine, Peking University First Hospital, 100034, Beijing, P. R. China.
Guanshu LiuRussell H. Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205, USA.ORCID http://orcid.org/0000-0002-8188-4332
Kennedy Krieger Institute · USPeking University · CNFirst Affiliated Hospital of Jinan University · CNJohns Hopkins University · US

Funding

Specific Molecular Imaging Agents for Clear Cell Renal Cell Carcinoma DiagnosisR03CA197470 · NCI · JOHNS HOPKINS UNIVERSITY · PI YANG, XING · 2015 to 2016
$162k
Optimization of CEST MRI for detection of bacteriaR03EB021573 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI LIU, GUANSHU · 2016 to 2017
$162k
NCI NIH HHS R03 CA197470NIBIB NIH HHS R03 EB021573NIH HHS NIH R03CA197470
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) MRI has recently emerged as a versatile molecular imaging approach in which diamagnetic compounds can be utilized to generate an MRI signal. To expand the scope of CEST MRI applications, herein, we systematically investigated the CEST properties of N-aryl amides with different N-aromatic substitution, revealing their chemical shifts (4.6-5.8 ppm) and exchange rates (up to thousands s

Indexed as

AmidesContrast MediaMagnetic Resonance ImagingMolecular ImagingAmidesContrast Mediaacebutolol metabolismCEST MRIenzyme detectionMRI contrast agentN-aryl amides

Identifiers

PMID32639618
PMCPMC10186200
OpenAlexW3041693347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.