ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2021
Prediction of local fixed charge density loss in cartilage following ACL injury and reconstruction: A computational proof-of-concept study with MRI follow-up.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Neural Network-Driven Finite Element Modeling for Estimating Knee Joint Cartilage Mechanical Responses.Annals of biomedical engineering · 2026Article
- Personalized musculoskeletal models show that gait biofeedback alters knee cartilage contact mechanics in ACL-reconstructed subjects.Journal of biomechanics · 2026Article
- Synergistic targeting of senolytic and senomorphic action with dual-engineered biomimetic macrophage nanovesicles for mitigating osteoarthritis.Bioactive materials · 2026Article
- Cartilage mechanical responses during gait as in silico biomarkers for medial knee OA progression.Scientific reports · 2025Article
- Time-dependent computational model of post-traumatic osteoarthritis to estimate how mechanoinflammatory mechanisms impact cartilage aggrecan content.PLoS computational biology · 2025Article
- Implication of region-dependent material properties of articular cartilage in the contact mechanics of porcine knee joint.BMC musculoskeletal disorders · 2025Article
- Three-Dimensional-Printed Osteochondral Scaffold with Biomimetic Surface Curvature for Osteochondral Regeneration.Pharmaceutics · 2025Article
- Infrared Spectroscopy Can Differentiate Between Cartilage Injury Models: Implication for Assessment of Cartilage Integrity.Annals of biomedical engineering · 2024Article
- Model Properties and Clinical Application in the Finite Element Analysis of Knee Joint: A Review.Orthopaedic surgery · 2024Review
- Biomechanical effects of typical lower limb movements of Chen-style Tai Chi on knee joint.Medical & biological engineering & computing · 2023Article
- Towards a Transferable Modeling Method of the Knee to Distinguish Between Future Healthy Joints from Osteoarthritic Joints: Data from the Osteoarthritis Initiative.Annals of biomedical engineering · 2023Article
- Adaptation of Fibril-Reinforced Poroviscoelastic Properties in Rabbit Collateral Ligaments 8 Weeks After Anterior Cruciate Ligament Transection.Annals of biomedical engineering · 2023Article
- Assessment of reporting practices and reproducibility potential of a cohort of published studies in computational knee biomechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Injury-related cell death and proteoglycan loss in articular cartilage: Numerical model combining necrosis, reactive oxygen species, and inflammatory cytokines.PLoS computational biology · 2023Article
- Signatures of disease progression in knee osteoarthritis: insights from an integrated multi-scale modeling approach, a proof of concept.Frontiers in bioengineering and biotechnology · 2023Article
- Site- and Zone-Dependent Changes in Proteoglycan Content and Biomechanical Properties of Bluntly and Sharply Grooved Equine Articular Cartilage.Annals of biomedical engineering · 2022Article
- Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis-Finite element modeling and MRI follow-up of ACL reconstructed patients.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Shear strain and inflammation-induced fixed charge density loss in the knee joint cartilage following ACL injury and reconstruction: A computational study.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait.PLoS computational biology · 2022Article
- A review of musculoskeletal modelling of human locomotion.Interface focus · 2021Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The purpose of this proof-of-concept study was to develop three-dimensional patient-specific mechanobiological knee joint models to simulate alterations in the fixed charged density (FCD) around cartilage lesions during the stance phase of the walking gait. Two patients with anterior cruciate ligament (ACL) reconstructed knees were imaged at 1 and 3 years after surgery. The magnetic resonance imaging (MRI) data were used for segmenting the knee geometries, including the cartilage lesions. Based on these geometries, finite element (FE) models were developed. The gait of the patients was obtained using a motion capture system. Musculoskeletal modeling was utilized to calculate knee joint contact and lower extremity muscle forces for the FE models. Finally, a cartilage adaptation algorithm was implemented in both FE models. In the algorithm, it was assumed that excessive maximum shear and deviatoric strains (calculated as the combination of principal strains), and fluid velocity, are responsible for the FCD loss. Changes in the longitudinal T
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