Evidence map›Paper›PMID 32639332›Full record

ArticleRetina (Philadelphia, Pa.)2021

ULTRA-WIDE FIELD FUNDUS AUTOFLUORESCENCE IMAGING OF EYES WITH STICKLER SYNDROME.

Kazushi Fujimoto, Tatsuo Nagata, Itsuka Matsushita, Kazuma Oku, Mamika Imagawa, Kazuki Kuniyoshi, Takaaki Hayashi, Kenichi Kimoto, Masahito Ohji, Shunji Kusaka and 1 more

Registry-linked trialOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Retina (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07146516 (Ora Secunda Cerclage Laser Retinopexy To Prevent Retinal Detachment In Stickler Syndrome), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07146516 narecruitingnot on this mapstarted 2025, after this paper: background citation

Ora Secunda Cerclage Laser Retinopexy To Prevent Retinal Detachment In Stickler Syndrome (OSC/SS): A Prospective Historically Controlled Study

TypeinterventionalSponsorHelen Keller Eye Research FoundationRan2025 to 2035Enrolled500ConditionsStickler Syndrome Type 1, Stickler Syndrome Type 2ArmsProphylactic (non-invasive) Laser Retinopexy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Ocular clinical characteristics and surgical outcomes of patients with stickler syndrome.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Kazushi FujimotoDepartment of Ophthalmology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Tatsuo NagataDepartment of Ophthalmology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Itsuka MatsushitaDepartment of Ophthalmology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kazuma OkuDepartment of Ophthalmology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Mamika ImagawaDepartment of Ophthalmology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Kazuki KuniyoshiDepartment of Ophthalmology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Takaaki HayashiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Kenichi KimotoDepartment of Ophthalmology, Oita University, Oita, Japan; and.
Masahito OhjiDepartment of Ophthalmology, Shiga University of Medical Science, Otsu, Japan.
Shunji KusakaDepartment of Ophthalmology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Hiroyuki KondoDepartment of Ophthalmology, University of Occupational and Environmental Health, Kitakyushu, Japan.
University of Occupational and Environmental Health Japan · JPKindai University · JPJikei University School of Medicine · JPOita University · JPShiga University of Medical Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine the characteristics of fundus autofluorescence (FAF) images and visual functions in eyes with Stickler syndrome using ultra-widefield FAF images.

methodsForty-six eyes of 26 patients with mutations in the COL2A1 gene underwent ultra-widefield FAF imaging. The eyes were categorized into three types; no signs of abnormal AF, predominantly hyperfluorescent AF (hyper-AF), and predominantly hypofluorescent AF (hypo-AF). Goldmann perimetry was performed on 34 eyes, and line-scan images of the abnormal AF lesions were obtained by swept-source optical coherence tomography in 4 eyes.

resultsAbnormal AF lesions were found in 37 eyes of 21 (80.7%) of the 26 patients. Hyper-AF was found in 15 eyes and hypo-AF was found in 22 eyes. The FAF changes corresponded with the funduscopically observed radial paravascular retinal degeneration. The average age at the examination was significantly younger in patients who had eyes with hyper-AF or no abnormal AF than in those with hypo-AF (12.8 vs. 28.4 years; P = 0.009). Abnormal AF-associated visual field defects were found in 5/10 (50%) eyes with hyper-AF and 17/18 (94%) eyes with hypo-AF. Hyper-AF changes tended to appear before retinal changes were detectable by fluorescein angiography. An absence of the ellipsoid zone and the outer nuclear layer and a thinning of the overall retinal thickness were found corresponding to the hypo-AF lesions in the swept source optical coherence tomography images.

conclusionAbnormal FAF is characteristic of eyes with Stickler syndrome. Age-related alterations of the FAF was associated with visual field defects and disruption of the photoreceptors and retinal pigment epithelial cells.

Indexed as

Optical ImagingVisual AcuityAdolescentAdultArthritisChildChild, PreschoolConnective Tissue DiseasesFemaleFluorescein AngiographyFollow-Up StudiesFundus OculiHearing Loss, SensorineuralHumansMaleMiddle Aged

Identifiers

PMID32639332
PMCPMC7889284
OpenAlexW3040948939

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.