ArticleeLife2020
Modular output circuits of the fastigial nucleus for diverse motor and nonmotor functions of the cerebellar vermis.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 1 of them a synthesis that pooled it.
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Who cites it
159 citing papers in PubMed, 1 synthesis or guideline pooled it, 248 citations in OpenAlex.
- A Systematic Review of Direct Outputs from the Cerebellum to the Brainstem and Diencephalon in Mammals.Cerebellum (London, England) · 2024Pooled it
- Investigation the concurrent effects of multi-session anodal tDCS and postural training on postural stability and functional balance in patients with multiple sclerosis: cerebellum versus dorsolateral prefrontal cortex stimulation.Brain structure & function · 2025Trial
- AAV-delivered TurboRFP enables streamlined tracing and analysis of corticospinal tract sprouting.Cell reports methods · 2026Article
- The cerebellum exploits a thalamic carrier frequency to refine motor behaviors.bioRxiv : the preprint server for biology · 2026Article
- Anatomy of Cerebro-cerebellar Circuits in Motor Control.Cerebellum (London, England) · 2026Review
- Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation.International journal of molecular sciences · 2026Review
- Generation and Validation of an Acan-Cre Mouse Line to Selectively Label Class-B Excitatory Neurons of the Cerebellar Nuclei.Cerebellum (London, England) · 2026Article
- Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026Article
- Review
- Specialized outputs and behavioral contributions of Purkinje cell subtypes.bioRxiv : the preprint server for biology · 2026Article
- Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1.Neurobiology of disease · 2026Article
- Region- and cell type-specific changes in gene expression in the cerebellum after classical fear conditioning.Communications biology · 2026Article
- Cerebellar acceleration of learning in an evidence-accumulation task.Cell reports · 2026Article
- Article
- High-Resolution Diffusion Tensor Imaging of the Cerebellum and Brainstem in Chiari Malformation Type I: Association with Function and Pain.Cerebellum (London, England) · 2026Article
- Ground-truth encoding of self-motion in the primate cerebellar nodulus and uvula.Nature communications · 2026Article
- The effects of iTBS to cerebellar vermis on balance function in frail older people: A protocol for a randomized controlled trial.PloS one · 2026Article
- Brain-wide mapping of developmental trajectories of cerebellar efferent projections.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mapping hippocampal-cerebellar functional connectivity across the human adult lifespan.Communications biology · 2025Article
- The cerebellar components of the human language network.bioRxiv : the preprint server for biology · 2025Article
99 more citing papers are in PubMed but not listed here.
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3 authors at 1 institution in 1 country.
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Abstract
The cerebellar vermis, long associated with axial motor control, has been implicated in a surprising range of neuropsychiatric disorders and cognitive and affective functions. Remarkably little is known, however, about the specific cell types and neural circuits responsible for these diverse functions. Here, using single-cell gene expression profiling and anatomical circuit analyses of vermis output neurons in the mouse fastigial (medial cerebellar) nucleus, we identify five major classes of glutamatergic projection neurons distinguished by gene expression, morphology, distribution, and input-output connectivity. Each fastigial cell type is connected with a specific set of Purkinje cells and inferior olive neurons and in turn innervates a distinct collection of downstream targets. Transsynaptic tracing indicates extensive disynaptic links with cognitive, affective, and motor forebrain circuits. These results indicate that diverse cerebellar vermis functions could be mediated by modular synaptic connections of distinct fastigial cell types with posturomotor, oromotor, positional-autonomic, orienting, and vigilance circuits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.