ArticleHuman brain mapping2020
Multiparameter mapping of relaxation (R1, R2*), proton density and magnetization transfer saturation at 3 T: A multicenter dual-vendor reproducibility and repeatability study.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Longitudinal relaxation rate (Magma (New York, N.Y.) · 2025Pooled it
- Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology.NeuroImage · 2021Pooled it
- Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury.Nature communications · 2026Trial
- An Open-Source, Reproducible MRI Data Acquisition and Reconstruction Workflow Using Pulseq: Multi-Site and Cross-Vendor Validation.Magnetic resonance in medicine · 2026Article
- Investigating effects of day-to-day variations in environmental exposure on the human brain: study protocol for the Day2Day Environment project.BMC neuroscience · 2026Article
- Reducing Motion Artifact in High Resolution 7 T MRI Using the Magnetic Resonance Minimal Motion ("MR-MinMo") Head Stabilization Device.Magnetic resonance in medicine · 2026Article
- Multimodal Quantitative MRI of White and Gray Matter: Associations with Myelin-Related Metrics in the Healthy Adult Brain Using Synthetic MRI and IVIM-DWI.Journal of clinical medicine · 2026Article
- Visual field inhomogeneities and the architectonics of early visual cortex shape visual working memory.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Multi-contrast dual-resolution UTE for myelin fraction mapping and structural imaging.Magma (New York, N.Y.) · 2026Article
- Analytical Dual Flip Angle R1 Calculation Outside the Small-Angle Regime.Magnetic resonance in medicine · 2026Article
- Scan-rescan reproducibility and interobserver reliability of T1 and T2 measurements of extraocular muscles using a multi-dynamic multi-echo MRI sequence.BMC medical imaging · 2026Article
- Development of a multi-parametric MRI platform to evaluate steady-state water content and optical properties in multiple ex vivo bovine lens.Experimental eye research · 2026Article
- Motor learning induces myelin-related white matter changes revealed by MRI-based in vivo histology.Communications biology · 2026Article
- Microstructure-informed deep learning improves thalamic atrophy segmentation and clinical associations in multiple sclerosis and related neuroimmunological diseases.NeuroImage. Clinical · 2026Article
- Quantitative MRI of the hippocampus reveals microstructural trajectories of aging and Alzheimer's disease pathology.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Towards quantitative intensity analysis of conventional T1-weighted images in multiple sclerosis.NeuroImage · 2025Article
- Microstructural abnormalities in multiple system atrophy as revealed by conventional and rotating frame relaxation MRI parameters.Scientific reports · 2025Article
- MPRAGEMagnetic resonance in medicine · 2025Article
- Comparison of test-retest repeatability of DESPOT and 3D-QALAS for TQuantitative imaging in medicine and surgery · 2025Article
- Longitudinal Changes of Quantitative Brain Tissue Properties Induced by Balance Training.Human brain mapping · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
Abstract
Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole-brain coverage. Within ~20 min, four MPM metrics (magnetization transfer saturation [MT], proton density [PD], longitudinal [R1], and effective transverse [R2*] relaxation rates) were measured using an optimized 1 mm isotropic resolution protocol on six 3 T MRI scanners from two different vendors. The same five healthy participants underwent two scanning sessions, on the same scanner, at each site. MPM metrics were calculated using the hMRI-toolbox. To account for different MT pulses used by each vendor, we linearly scaled the MT values to harmonize them across vendors. To determine longitudinal repeatability and inter-site comparability, the intra-site (i.e., scan-rescan experiment) coefficient of variation (CoV), inter-site CoV, and bias across sites were estimated. For MT, R1, and PD, the intra- and inter-site CoV was between 4 and 10% across sites and scan time points for intracranial gray and white matter. A higher intra-site CoV (16%) was observed in R2* maps. The inter-site bias was below 5% for all parameters. In conclusion, the MPM protocol yielded reliable quantitative maps at high resolution with a short acquisition time. The high reproducibility of MPM metrics across sites and scan time points combined with its tissue microstructure sensitivity facilitates longitudinal multicenter imaging studies targeting microstructural changes, for example, as a quantitative MRI biomarker for interventional clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.