ArticleJournal of psychopharmacology (Oxford, England)2020
Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents and beta-blockers: An electronic health records network study.
Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Cross national pharmacovigilance analysis of drug-induced delirium: a comparative study using the US FAERS, Japanese JADER, and canadian CVAR datasets.Frontiers in pharmacology · 2026Article
- Recent advances in postoperative delirium in elderly patients: pathophysiological mechanisms, risk prediction, and therapeutic strategies.Frontiers in neuroscience · 2026Review
- The intersection of delirium and long-term cognition in older adults: the critical role of delirium prevention.Journal of neurology · 2025Review
- Association of Hypertension with Different Cognitive Disorders.Journal of clinical medicine · 2024Review
- Types, predictors, and consequences of medicines related problems (MRPs) in frail older adults admitted to hospital from primary care - A retrospective cohort study.Exploratory research in clinical and social pharmacy · 2024Article
- The State of Use and Utility of Negative Controls in Pharmacoepidemiologic Studies.American journal of epidemiology · 2024Review
- Intraoperative neurological pupil index and postoperative delirium and neurologic adverse events after cardiac surgery: an observational study.Scientific reports · 2023Observational
- Relationship between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prescribing and delirium in the ICU-A secondary analysis.Journal of the American Geriatrics Society · 2023Article
- Complications Associated With Transesophageal Echocardiography in Transcatheter Structural Cardiac Interventions.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023Article
- CACNA1C (CaNeuropharmacology · 2022Review
- Tic Disorders, Anti-Tic Medications, and Risk of Atopy.Movement disorders clinical practice · 2022Article
- Brain-penetrant calcium channel blockers are associated with a reduced incidence of neuropsychiatric disorders.Molecular psychiatry · 2022Article
- Low Adherence to Kidney Disease: Improving Global Outcomes 2012 CKD Clinical Practice Guidelines Despite Clear Evidence of Utility.Kidney international reports · 2022Article
- Potential effects of regular use of antihypertensive drugs for in-hospital delirium in geriatric patients with trauma.Scientific reports · 2022Article
- Immune Checkpoint Inhibitors-Associated Cardiotoxicity.Cancers · 2022Article
- Data-driven identification of temporal glucose patterns in a large cohort of nondiabetic patients with COVID-19 using time-series clustering.JAMIA open · 2021Article
- Onset and recurrence of psychiatric disorders associated with anti-hypertensive drug classes.Translational psychiatry · 2021Article
- A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States.Scientific reports · 2021Article
- Neuropsychiatric Consequences of Lipophilic Beta-Blockers.Medicina (Kaunas, Lithuania) · 2021Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntihypertensive drugs, especially calcium channel blockers, have been associated with differential rates of a number of neuropsychiatric outcomes. Delirium is commonly attributed to medication, including antihypertensive drugs, but delirium incidence has not been compared directly between antihypertensive drug classes.
methodsUsing a federated electronic health records network of 25.5 million people aged 50 years or older, we measured rates of delirium over a two-year period in patients prescribed calcium channel blockers compared to the other main antihypertensive drug classes. Extensive propensity score matching was used to create cohorts matched for a range of demographic factors and delirium risk factors. Negative control outcomes were also measured.
resultsCohort sizes ranged from 54,000-577,000. Delirium was more common with calcium channel blockers than with renin-angiotensin system agents (~40% higher) but less common than with beta-blockers (~20% lower). These differences remained when patients with a range of other delirium risk factors were excluded, and they were not paralleled by the negative control outcomes. Comparisons between calcium channel blockers and diuretics produced inconclusive results.
conclusionsCalcium channel blockers are associated with higher rates of delirium than renin-angiotensin system agents, but lower rates compared to beta-blockers. The findings add to the list of factors which may be considered when choosing antihypertensive drug class.
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