Evidence map›Paper›PMID 32638562›Full record

ArticleAllergy, asthma & immunology research2020

Coexisting COPD Increases Mortality in Patients With Corticosteroid-Dependent Asthma: A Nationwide Population-Based Study.

Hyun Lee, Jiin Ryu, Sung Jun Chung, Dong Won Park, Jang Won Sohn, Ho Joo Yoon, Sang Heon Kim

Open access · diamondAbstract read
In one paragraph

Article in Allergy, asthma & immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Hyun Lee *Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-1269-0913
Jiin Ryu *Biostatistical Consulting and Research Lab, Medical Research Collaborating Center, Hanyang University, Seoul, Korea.ORCID https://orcid.org/0000-0001-9763-5413
Sung Jun ChungDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8636-446X
Dong Won ParkDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4538-6045
Jang Won SohnDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7132-2988
Ho Joo YoonDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-4645-4863
Sang Heon KimDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. sangheonkim@hanyang.ac.kr.ORCID https://orcid.org/0000-0001-8398-4444
Hanyang University · KRBiostatistical Consulting (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChronic corticosteroid (CS) use is a risk factor for long-term mortality in asthmatic patients, and the presence of coexisting chronic obstructive pulmonary disease (COPD) is associated with a severe presentation and poor prognosis. However, the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma has not been well elucidated. This study aimed to determine the impact of coexisting COPD on long-term mortality in patients with CS-dependent asthma.

methodsA retrospective cohort of patients with CS-dependent asthma aged 40 years or older was established using records from the Korean National Health Insurance Service database for 2005 to 2015. We classified the subjects into 2 groups according to the presence of COPD and evaluated the hazard ratio (HR) for all-cause mortality in patients with COPD relative to those without COPD.

resultsOf 8,021 patients with CS-dependent asthma, 3,121 (38.9%) had COPD. All-cause mortality was significantly greater in patients with CS-dependent asthma and COPD than in those without COPD (9,955/100,000 person-years vs. 5,585/100,100 person-years,

conclusionsIn this population-based retrospective cohort study, the presence of physician-recognized COPD was associated with greater all-cause mortality and greater risk of mortality due to chronic lower respiratory diseases and lung cancer in patients with CS-dependent asthma. Early recognition and appropriate management of COPD can improve treatment outcomes in patients with CS-dependent asthma.

Indexed as

asthmachronic obstructive pulmonary diseaseMortalitypopulationsteroidstreatment

Identifiers

PMID32638562
PMCPMC7346996
OpenAlexW3039034332

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.