Evidence map›Paper›PMID 32638415›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Network determinants of cardiovascular calcification and repositioned drug treatments.

Euijun Song, Rui-Sheng Wang, Jane A Leopold, Joseph Loscalzo

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Medial Arterial Calcification: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2021
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Network determinants of cardiovascular calcification and repositioned drug treatments.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Euijun SongDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rui-Sheng WangDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Jane A LeopoldDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joseph LoscalzoDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · US

Funding

Boston Biomedical Innovation CenterU54HL119145 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GOLAN, DAVID E., LOSCALZO, JOSEPH · 2013 to 2021
$18.8M
Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
The Phathophenotype Landscape of Complex DiseaseU01HL108630 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2011 to 2014
$2.7M
Intergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7M
NHGRI NIH HHS U01 HG007690NHLBI NIH HHS U01 HL108630NHLBI NIH HHS U01 HL125215NHLBI NIH HHS U54 HL119145
6 · The paper itself

Abstract

Ectopic cardiovascular calcification is a highly prevalent pathology for which there are no effective novel or repurposed pharmacotherapeutics to prevent disease progression. We created a human calcification endophenotype module (ie, the "calcificasome") by mapping vascular calcification genes (proteins) to the human vascular smooth muscle-specific protein-protein interactome (218 nodes and 632 edges, P < 10

Indexed as

CalcinosisCells, CulturedCoronary VesselsFibrosisHumansInflammationMuscle, Smooth, VascularMyocytes, Smooth MusclePharmaceutical PreparationsThrombosisVascular CalcificationPharmaceutical Preparationsblood vesselcalcificationprotein interactionsmooth muscle celltherapeutics

Identifiers

PMID32638415
PMCPMC7497212
OpenAlexW3041779359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.