ArticleAntimicrobial agents and chemotherapy1988
Effects of amodiaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro.
Article in Antimicrobial agents and chemotherapy, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- Matrix metallopeptidase 9 as a host protein target of chloroquine and melatonin for immunoregulation in COVID-19: A network-based meta-analysis.Life sciences · 2020Pooled it
- Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria.Antimicrobial agents and chemotherapy · 2006Trial
- Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria.Antimicrobial agents and chemotherapy · 2005Trial
- Elevated Inflammation Associated with Markers of Neutrophil Function and Gastrointestinal Disruption in Pilot Study ofViruses · 2024Article
- Oxidative Stress, Proton Fluxes, and Chloroquine/Hydroxychloroquine Treatment for COVID-19.Antioxidants (Basel, Switzerland) · 2020Review
- Neutrophil extracellular traps in breast cancer and beyond: current perspectives on NET stimuli, thrombosis and metastasis, and clinical utility for diagnosis and treatment.Breast cancer research : BCR · 2019Review
- Modulation of Neutrophil Extracellular Trap and Reactive Oxygen Species Release by Periodontal Bacteria.Infection and immunity · 2017Article
- Studying the effect of chloroquine on sporozoite-induced protection and immune responses in Plasmodium berghei malaria.Malaria journal · 2015Article
- Identification and characterisation of small molecule inhibitors of feline coronavirus replication.Veterinary microbiology · 2014Article
- Mefloquine, an anti-malaria agent, causes reactive oxygen species-dependent cell death in mast cells via a secretory granule-mediated pathway.Pharmacology research & perspectives · 2014Article
- The presence of leukocytes in ex vivo assays significantly increases the 50-percent inhibitory concentrations of artesunate and chloroquine against Plasmodium vivax and Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2011Article
- Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum.Antimicrobial agents and chemotherapy · 2004Article
- Effect of proinflammatory cytokines on the interplay between roxithromycin, HMR 3647, or HMR 3004 and human polymorphonuclear neutrophils.Antimicrobial agents and chemotherapy · 2000Article
- Interactions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils.Antimicrobial agents and chemotherapy · 1998Article
- Mechanism of clozapine-induced agranulocytosis : current status of research and implications for drug development.CNS drugs · 1997Article
- Effects of anti-infectious agents on polymorphonuclear neutrophils.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1991Review
- Activity of intracellular antibiotics.Infection · 1991Article
- New concepts in antimalarial use and mode of action in dermatology.Dermatologic therapyReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study concerns the in vitro interaction with human polymorphonuclear neutrophils (PMNs) of amodiaquine, chloroquine, and mefloquine, three antimalarial drugs currently in use for the treatment and prophylaxis of malaria. It was found that mefloquine (100 and 50 micrograms/ml) significantly altered PMN viability while the other two drugs did not. Neutrophil chemotaxis was impaired by chloroquine (100 micrograms/ml) and mefloquine (greater than 10 micrograms/ml) but not by amodiaquine. Phagocytosis was decreased by about 50% in the presence of chloroquine (100 micrograms/ml) or mefloquine (10 micrograms/ml). The three antimalarial drugs altered neutrophil oxidative metabolism as assessed by luminol-amplified chemiluminescence. The strongest effect was observed with mefloquine, which abolished almost completely the neutrophil burst at concentrations of greater than 10 micrograms/ml whatever the stimulus used. This effect was not reversed by washing. Chloroquine and amodiaquine also impaired this PMN response by approximately 80 and 50%, respectively, but only at the highest concentration used (100 micrograms/ml). In the case of amodiaquine, the neutrophil response was restored by washing, except for stimulation with opsonized particles. After washing, the depressive effect of chloroquine was reversed completely in the case of phorbol myristate acetate stimulation and partly in the case of opsonized particle stimulation, but the formylmethionyl-leucyl-phenylalanine-induced response was not restored. These data show that although they are structurally related, amodiaquine and chloroquine exhibit qualitatively and quantitatively different depressive effects on PMN function and probably interfere at different points of cell activation, although the precise mechanisms are as yet unresolved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.